L
Lei Lv
Researcher at Huazhong Agricultural University
Publications - 12
Citations - 114
Lei Lv is an academic researcher from Huazhong Agricultural University. The author has contributed to research in topics: Rabies virus & Immune system. The author has an hindex of 4, co-authored 10 publications receiving 39 citations.
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Journal ArticleDOI
A novel antiviral lncRNA, EDAL, shields a T309 O -GlcNAcylation site to promote EZH2 lysosomal degradation
Baokun Sui,Dong Chen,Wei Liu,Qiong Wu,Bin Tian,Yingying Li,Jing Hou,Shiyong Liu,Juan Xie,Hao Jiang,Zhaochen Luo,Lei Lv,Fei Huang,Ruiming Li,Chengguang Zhang,Yuling Tian,Min Cui,Ming Zhou,Huanchun Chen,Zhen F. Fu,Zhen F. Fu,Yi Zhang,Ling Zhao +22 more
TL;DR: Findings show that a neuronal lncRNA can exert an effective antiviral function via blocking a specific O-GlcNAcylation that determines EZH2 lysosomal degradation, rather than the traditional interferon-dependent pathway.
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Toll-Like Receptor 7 Enhances Rabies Virus-Induced Humoral Immunity by Facilitating the Formation of Germinal Centers.
Zhaochen Luo,Yingying Li,Ming Zhou,Lei Lv,Qiong Wu,Chen Chen,Yachun Zhang,Baokun Sui,Changchun Tu,Min Cui,Huanchun Chen,Zhen F. Fu,Zhen F. Fu,Ling Zhao +13 more
TL;DR: Results suggest that TLR7 facilitates the induction of the humoral immunity in response to RABV, and down-regulation of some cytokines/chemokines results in a Th2-biased antibody production.
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Interferon-λ Attenuates Rabies Virus Infection by Inducing Interferon-Stimulated Genes and Alleviating Neurological Inflammation.
Yingying Li,Ling Zhao,Zhaochen Luo,Yachun Zhang,Lei Lv,Jianqing Zhao,Baokun Sui,Fei Huang,Min Cui,Zhen F. Fu,Ming Zhou +10 more
TL;DR: The role of IFN-λ in inhibiting RABV infection is underscored, which potentiates IFn-λ as a possible therapeutic agent for the treatment of RABv infection.
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Composition of the murine gut microbiome impacts humoral immunity induced by rabies vaccines.
Yachun Zhang,Qiong Wu,Ming Zhou,Zhaochen Luo,Lei Lv,Jie Pei,Caiqian Wang,Benjie Chai,Baokun Sui,Fei Huang,Zhen F. Fu,Ling Zhao +11 more
TL;DR: The results provide the evidence that the gut microbiome impacts humoral immunity post rabies vaccination, and further investigation of the mechanism will help the development of novel adjuvants and vaccines.
Journal ArticleDOI
Dihydroartemisinin regulates immune cell heterogeneity by triggering a cascade reaction of CDK and MAPK phosphorylation
Qilong Li,Quan Yuan,Ning Jiang,Yiwei Zhang,Ziwei Su,Lei Lv,Xiaoyu Sang,Ran Chen,Ying Feng,Qijun Chen +9 more
TL;DR: Wang et al. as discussed by the authors showed that DHA selectively induced T-cell activation, with an increased proportion of Ki67+CD4+ T cells, CD25+CD 4+T cells, interferon (IFN)-γ-producing CD8+ T cell, Brdu+ CD8+, and neutrophils, which was found to enhance cellular immunity to experimental malaria and overcome immunosuppression in mice.