Chengguang Zhang

TL;DR: Findings show that a neuronal lncRNA can exert an effective antiviral function via blocking a specific O-GlcNAcylation that determines EZH2 lysosomal degradation, rather than the traditional interferon-dependent pathway.

TL;DR: Results demonstrate that MPLA serving as an adjuvant enhances the intensity of humoral immune responses by activating the cDC–Tfh–GC B axis, which will contribute to the improvement of the efficiency of traditional rabies vaccines.

TL;DR: The feasibility of developing novel rabies vaccines based on the self-replicating PRPs is revealed, and VEEV-RABV-G could self-propagate efficiently in cell culture and induce a robust humoral immunity and provide protection against virulent RABV challenge in immunized mice.

TL;DR: In this article, the effect of colloidal manganese salt (Mn jelly [MnJ]) as an adjuvant of rabies vaccine was evaluated in mice, cats, and dogs.

TL;DR: In this article, the authors constructed novel VLVs by transfection of a mutant Semliki Forest virus (SFV) RNA replicon encoding Rabies virus glycoprotein (RABV-G), which could self-propagate efficiently in cell culture and evolve to high titers.