Lei Sun

TL;DR: Human cytomegalovirus (HCMV) down-regulates expression of MHC class I products by selective proteolysis by encodes an endoplasmic reticulum resident type-I transmembrane glycoprotein, which dislocates newly synthesized class I molecules from the ER to the cytosol, where they are acted upon by an N-glycanase and the proteasome.

TL;DR: The data suggest that gpUS3 impairs egress of MHC class I heavy chains from the endoplasmic reticulum.

TL;DR: Human cytomegalovirus can modify the chemokine environment of infected cells through intense sequestering of CC chemokines, mediated principally by expression of the US28-encodedChemokine receptor.

TL;DR: The role of pUL97 in the HCMV replication cycle, and the mechanism by which it causes phosphorylation of GCV, are currently unknown as mentioned in this paper, however, the authors of this paper have shown that pUL-97 is a virion phosphoprotein, and a likely tegument component.

TL;DR: Examination of the CL13933 loading patterns of wild type and the five mutant proteases by mass spectrometry revealed that residues Cys87, Cys138, and Cys161 react with CL 13933, and that the disulfide pair partner of each is able to displace the compound via thiol-disulfide exchange.