M
Marshall M. Siegel
Researcher at Princeton University
Publications - 27
Citations - 1340
Marshall M. Siegel is an academic researcher from Princeton University. The author has contributed to research in topics: Mass spectrometry & Electrospray ionization. The author has an hindex of 16, co-authored 27 publications receiving 1270 citations. Previous affiliations of Marshall M. Siegel include American Cyanamid.
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Journal ArticleDOI
Calichemicins, a novel family of antitumor antibiotics. 2. Chemistry and structure of calichemicin .gamma.1I
May D. Lee,T. S. Dunne,Conway C. Chang,George A. Ellestad,Marshall M. Siegel,George O. Morton,William J. McGahren,Donald B. Borders +7 more
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Structures of the muraymycins, novel peptidoglycan biosynthesis inhibitors
Leonard A. McDonald,Laurel R. Barbieri,Guy T. Carter,Eileen Lenoy,Jason A. Lotvin,Peter Petersen,Marshall M. Siegel,Guy Singh,R. Thomas Williamson +8 more
TL;DR: One of the most active compounds, muraymycin A1, demonstrated protection in vivo against Staphylococcus aureus infection in mice (ED50 1.1 mg/kg), and constituted a new antibiotic family whose core structure contains a glycosylated uronic acid derivative joined by an aminopropane group.
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Calicheamicins, a novel family of antitumor antibiotics. 4. Structure elucidation of calicheamicins .beta.1Br, .gamma.1Br, .alpha.2I, .alpha.3I, .beta.1I, .gamma.1I, and .delta.1I
May D. Lee,T. S. Dunne,Conway C. Chang,Marshall M. Siegel,George O. Morton,George A. Ellestad,William J. McGahren,Donald B. Borders +7 more
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Further evidence that a cell wall precursor [C(55)-MurNAc-(peptide)-GlcNAc] serves as an acceptor in a sorting reaction.
Alexey Ruzin,Anatoly Severin,Frank Ritacco,Keiko Tabei,Guy Singh,Patricia A. Bradford,Marshall M. Siegel,Steven J. Projan,David M. Shlaes +8 more
TL;DR: This study simplified the procedure for in vitro biosynthesis of Gly-containing lipid II by using branched UDP-MurNAc-hexapeptide isolated from the cytoplasm of Streptomyces spp.
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2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as covalent-binding, irreversible inhibitors of the kinase domain of vascular endothelial growth factor receptor-2.
Allan Wissner,M. Brawner Floyd,Bernard Dean Johnson,Heidi L. Fraser,Charles Ingalls,Thomas Nittoli,Russell Dushin,Carolyn Discafani,Ramaswamy Nilakantan,Joseph Marini,Malini Ravi,Kinwang Cheung,Xingzhi Tan,Sylvia Musto,Tami Annable,Marshall M. Siegel,Frank Loganzo +16 more
TL;DR: Unequivocal evidence, from mass spectral studies, indicates that these inhibitors form a covalent interaction with Cys-1045, and one member of this series displays antitumor activity in an in vivo model.