L
Leif Schröder
Researcher at Leibniz Institute for Neurobiology
Publications - 85
Citations - 2570
Leif Schröder is an academic researcher from Leibniz Institute for Neurobiology. The author has contributed to research in topics: Hyperpolarization (physics) & Xenon. The author has an hindex of 27, co-authored 78 publications receiving 2215 citations. Previous affiliations of Leif Schröder include German Cancer Research Center & University of California.
Papers
More filters
Journal ArticleDOI
Molecular Imaging Using a Targeted Magnetic Resonance Hyperpolarized Biosensor
Leif Schröder,Leif Schröder,Thomas J. Lowery,Thomas J. Lowery,Christian Hilty,Christian Hilty,David E. Wemmer,David E. Wemmer,Alexander Pines,Alexander Pines +9 more
TL;DR: This technique uses the signal of free hyperpolarized xenon to dramatically amplify the sensor signal via chemical exchange saturation transfer (CEST) and marks a critical step toward the application of xenon biosensors as selective contrast agents in biomedical applications.
Journal ArticleDOI
NMR Hyperpolarization Techniques of Gases.
Danila A. Barskiy,Aaron M. Coffey,Panayiotis Nikolaou,Dmitry M. Mikhaylov,Boyd M. Goodson,Rosa T. Branca,George J. Lu,Mikhail G. Shapiro,Ville-Veikko Telkki,Vladimir V. Zhivonitko,Igor V. Koptyug,Oleg G. Salnikov,Kirill V. Kovtunov,Valerii I. Bukhtiyarov,Matthew S. Rosen,Michael J. Barlow,Shahideh Safavi,Ian P. Hall,Leif Schröder,Eduard Y. Chekmenev,Eduard Y. Chekmenev +20 more
TL;DR: This Minireview covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.
Journal ArticleDOI
Xenon for NMR biosensing – Inert but alert
TL;DR: This review summarizes recent developments in the production of hyperpolarized xenon and the design and detection schemes of xenon biosensors.
Journal ArticleDOI
Development of an antibody-based, modular biosensor for 129Xe NMR molecular imaging of cells at nanomolar concentrations.
Honor May Rose,Christopher Witte,Federica Rossella,Stefan Klippel,Christian Freund,Leif Schröder +5 more
TL;DR: A functional xenon NMR biosensor that can identify a specific cell surface marker by targeted 129Xe MRI, designed in a versatile, modular fashion, that can be readily applied as the xenon MRI field moves closer to molecular imaging applications in vivo.
Journal ArticleDOI
Preparation of biogenic gas vesicle nanostructures for use as contrast agents for ultrasound and MRI
Anupama Lakshmanan,George J. Lu,Arash Farhadi,Suchita P. Nety,Martin Kunth,Audrey Lee-Gosselin,David Maresca,Raymond W. Bourdeau,Melissa Yin,Judy Yan,Christopher Witte,Dina Malounda,F. Stuart Foster,F. Stuart Foster,Leif Schröder,Mikhail G. Shapiro +15 more
TL;DR: A protocol for isolating GVs from native and heterologous host organisms, functionalizing these nanostructures with moieties for targeting and fluorescence, characterizing their biophysical properties and imaging them using ultrasound and MRI is provided.