C
Christian Hilty
Researcher at Texas A&M University
Publications - 108
Citations - 4780
Christian Hilty is an academic researcher from Texas A&M University. The author has contributed to research in topics: Hyperpolarization (physics) & Nuclear magnetic resonance spectroscopy. The author has an hindex of 35, co-authored 103 publications receiving 4218 citations. Previous affiliations of Christian Hilty include Centre national de la recherche scientifique & Baylor College of Medicine.
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Journal ArticleDOI
Molecular Imaging Using a Targeted Magnetic Resonance Hyperpolarized Biosensor
Leif Schröder,Leif Schröder,Thomas J. Lowery,Thomas J. Lowery,Christian Hilty,Christian Hilty,David E. Wemmer,David E. Wemmer,Alexander Pines,Alexander Pines +9 more
TL;DR: This technique uses the signal of free hyperpolarized xenon to dramatically amplify the sensor signal via chemical exchange saturation transfer (CEST) and marks a critical step toward the application of xenon biosensors as selective contrast agents in biomedical applications.
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Molecular mechanisms of ion-specific effects on proteins.
TL;DR: The specific binding sites of Hofmeister ions with an uncharged 600-residue elastin-like polypeptide, (VPGVG)(120), were elucidated using a combination of NMR and thermodynamic measurements along with molecular dynamics simulations and provide new insights into the mechanism of peptide-anion interactions.
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Effective rotational correlation times of proteins from NMR relaxation interference
TL;DR: A novel NMR pulse scheme, [15N,1H]-TRACT, is reported, which is based on transverse relaxation-optimized spectroscopy and permits to determine tauc for 15N-1H bonds without interference from dipole-dipole coupling of the amide proton with remote protons.
Journal ArticleDOI
Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy
Jan Henrik Ardenkjær-Larsen,Gregory S. Boebinger,Arnaud Comment,Simon B. Duckett,Arthur S. Edison,Frank Engelke,Christian Griesinger,Robert G. Griffin,Christian Hilty,Hidaeki Maeda,Giacomo Parigi,Thomas F. Prisner,Enrico Ravera,Jan van Bentum,Shimon Vega,Andrew G. Webb,Claudio Luchinat,Harald Schwalbe,Lucio Frydman +18 more
TL;DR: Several challenges remain in the quest of endowing NMR spectroscopy with the sensitivity that has characterized forms of spectroscopies based on electrical or optical measurements, and the ways by which scientists and engineers are striving to solve them are addressed.
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NMR structure of the integral membrane protein OmpX.
TL;DR: The present approach for de novo structure determination should be quite widely applicable to membrane proteins reconstituted in mixed micelles with overall molecular masses up to about 100 kDa, and may also provide a platform for additional functional studies.