Lena A. Berlemann

TL;DR: Mounting evidence indicates that PINK1 has additional functions, for example, in regulating complex I activity and maintaining neuronal viability in response to stress.

TL;DR: This work reports that various disease‐associated protein aggregates are modified by the linear ubiquitin chain assembly complex (LUBAC), identifying linear Ubiquitination as a protein quality control mechanism and hence a novel target for disease‐modifying strategies in proteinopathies.

TL;DR: It is found that PACRG played no role in mitophagy in cultured human cells but did promote NF-κB signaling downstream of the tumor necrosis factor (TNF) receptor TNFR1 and protected cells from TNF-induced apoptosis by interacting with and stabilizing the linear ubiquitin chain assembly complex (LUBAC).

TL;DR: In this paper , the authors show that the NF-κB pathway activated by TNF employs mitochondria as a platform for signal amplification and shuttling of activated NF•κB to the nucleus.

TL;DR: The prominent role of mitochondria in energy supply and cellular homeostasis highlights the importance of mitochondrial quality control mechanisms to preserve organelle function under stress and to eliminate irreversibly damaged mitochondria.