L
Lena Glaser
Researcher at Queen's University Belfast
Publications - 4
Citations - 52
Lena Glaser is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Burkholderia & Complement fixation test. The author has an hindex of 1, co-authored 4 publications receiving 24 citations.
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Journal ArticleDOI
Airway Epithelial Derived Cytokines and Chemokines and Their Role in the Immune Response to Respiratory Syncytial Virus Infection.
Lena Glaser,Patricia Coulter,Patricia Coulter,Michael D. Shields,Michael D. Shields,Olivier Touzelet,Ultan F. Power,Lindsay Broadbent +7 more
TL;DR: A broad review of the cytokines and chemokines secreted from human airway epithelial cell models during respiratory syncytial virus (RSV) infection based on a comprehensive literature review suggests chemo-attraction of peripheral immune cells as a key function of the epithelium.
Posted ContentDOI
A glycoengineered antigen exploiting a conserved protein O-glycosylation pathway in the Burkholderia genus for diagnosis of glanders infections
Guanbo Wang,Lena Glaser,Nichollas E. Scott,Yasmine Fathy Mohamed,Yasmine Fathy Mohamed,Rebecca J. Ingram,Karine Laroucau,Miguel A. Valvano +7 more
TL;DR: Results show 100 % specificity in the detection of antibodies from infected horses, indicating that protein O-glycosylation in Burkholderia can be exploited as a biomarker for diagnosis of Burk holderia-associated infections.
Journal ArticleDOI
A glycoengineered antigen exploiting a conserved protein O-glycosylation pathway in the Burkholderia genus for detection of glanders infections
Guanbo Wang,Lena Glaser,Nichollas E. Scott,Yasmine Fathy Mohamed,Yasmine Fathy Mohamed,Rebecca J. Ingram,Karine Laroucau,Miguel A. Valvano +7 more
TL;DR: In this article, a protein O-glycosylation pathway conserved in all species of the Burkholderia genus that results in the synthesis and incorporation of a trisaccharide glycan to membrane-exported proteins was described.
Journal ArticleDOI
Potential glycoengineered anti-Burkholderia vaccines by exploiting the bacterial O-glycosylation machinery
TL;DR: This work successfully produced two prototypes of anti-Burkholderia vaccines: a recombinant glycoprotein-based vaccine and an E. coli LPS-display vaccine, demonstrating that the O-glycosylation pathway can be manipulated for the construction of potential anti-burk holderia vaccines.