L
Lindsay Broadbent
Researcher at Queen's University Belfast
Publications - 19
Citations - 249
Lindsay Broadbent is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Respiratory epithelium & Virus. The author has an hindex of 8, co-authored 17 publications receiving 184 citations.
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Journal ArticleDOI
Respiratory syncytial virus, an ongoing medical dilemma: an expert commentary on respiratory syncytial virus prophylactic and therapeutic pharmaceuticals currently in clinical trials
TL;DR: This review presents an expert commentary on all RSV‐specific prophylactic and therapeutic candidates that have entered clinical trials since 2008 and concludes that there is still no specific therapeutics or vaccines to combat RSV.
Journal ArticleDOI
Induction and Antagonism of Antiviral Responses in Respiratory Syncytial Virus-Infected Pediatric Airway Epithelium
Remi Villenave,Lindsay Broadbent,Isobel Douglas,Jeremy Lyons,Peter V. Coyle,Michael N. Teng,Ralph A. Tripp,Liam G Heaney,Michael D. Shields,Michael D. Shields,Ultan F. Power +10 more
TL;DR: A model of respiratory syncytial virus (RSV) infection based on well-differentiated pediatric primary bronchial epithelial cell cultures (WD-PBECs) that mimics hallmarks of RSV disease in infants found that RSV induced a potent antiviral state in these cultures and that a type III interferon, interleukin IL-29 (IL-29), was involved.
Journal ArticleDOI
Airway Epithelial Derived Cytokines and Chemokines and Their Role in the Immune Response to Respiratory Syncytial Virus Infection.
Lena Glaser,Patricia Coulter,Patricia Coulter,Michael D. Shields,Michael D. Shields,Olivier Touzelet,Ultan F. Power,Lindsay Broadbent +7 more
TL;DR: A broad review of the cytokines and chemokines secreted from human airway epithelial cell models during respiratory syncytial virus (RSV) infection based on a comprehensive literature review suggests chemo-attraction of peripheral immune cells as a key function of the epithelium.
Book ChapterDOI
In Vitro Modeling of RSV Infection and Cytopathogenesis in Well-Differentiated Human Primary Airway Epithelial Cells (WD-PAECs).
Lindsay Broadbent,Remi Villenave,Hong Guo-Parke,Isobel Douglas,Michael D. Shields,Ultan F. Power +5 more
TL;DR: The development of a well-differentiated primary pediatric airway epithelial cell models (WD-PAECs) allows us to simulate several hallmarks of RSV infection of infant airways and represent important additions to RSV pathogenesis modeling in human-relevant tissues.
Journal ArticleDOI
Comparative primary paediatric nasal epithelial cell culture differentiation and RSV-induced cytopathogenesis following culture in two commercial media
Lindsay Broadbent,Sheerien Manzoor,Maria C. Zarcone,Judit Barabas,Michael D. Shields,Michael D. Shields,Sejal Saglani,Claire M. Lloyd,Andrew Bush,Adnan Custovic,Peter Ghazal,Mindy Gore,Ben Marsland,Graham Roberts,Jürgen Schwarze,Steve Turner,Ultan F. Power +16 more
TL;DR: The type of medium used for the differentiation of primary human airway epithelial cells may impact experimental results, and it is found that cultures generated using PneumaCult resulted in greater total numbers of smaller, tightly packed, pseudostratified cells.