E
Elaine Dzierzak
Researcher at University of Edinburgh
Publications - 165
Citations - 18348
Elaine Dzierzak is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 56, co-authored 161 publications receiving 16723 citations. Previous affiliations of Elaine Dzierzak include Erasmus University Medical Center & Erasmus University Rotterdam.
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Definitive Hematopoiesis Is Autonomously Initiated by the AGM Region
TL;DR: A novel in vitro organ culture system is presented demonstrating that, at day 10 in gestation, hematopoietic stem cells initiate autonomously and exclusively within the aorta-gonad-mesonephros (AGM) region, suggesting that the AGM region is the source of the definitive adult hematosynthesis system, which subsequently colonizes the liver.
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Development of hematopoietic stem cell activity in the mouse embryo
TL;DR: The long-term, complete, and functional hematopoietic repopulation of primary and serial recipients with AGM-derived cells is reported and potent hematopolietic stem cell activity in the AGM region is observed before the appearance of yolk sac and liver stemcell activity.
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Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter
TL;DR: It is shown by conditional deletion that Runx1 activity in vascular-endothelial-cadherin-positive endothelial cells is indeed essential for intra-arterial cluster, haematopoietic progenitor and HSC formation in mice.
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In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium
Jean-Charles Boisset,Wiggert A. van Cappellen,Charlotte Andrieu-Soler,Niels Galjart,Elaine Dzierzak,Catherine Robin +5 more
TL;DR: Time-lapse confocal imaging and a new dissection procedure are used and shown the dynamic de novo emergence of phenotypically defined HSCs (Sca1+, c-kit+, CD41+) directly from ventral aortic haemogenic endothelial cells.
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Of lineage and legacy: the development of mammalian hematopoietic stem cells
Elaine Dzierzak,Nancy A. Speck +1 more
TL;DR: A historical overview of and the most recent data on the developmental origins of hematopoiesis are presented, as these may prove useful for generating and expanding these clinically important cell populations ex vivo.