L
Lenore K. Beitel
Researcher at Montreal Neurological Institute and Hospital
Publications - 86
Citations - 3586
Lenore K. Beitel is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Androgen receptor & Androgen. The author has an hindex of 31, co-authored 84 publications receiving 3288 citations. Previous affiliations of Lenore K. Beitel include Jewish General Hospital & McGill University.
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Journal ArticleDOI
The androgen receptor gene mutations database: 2012 update
Bruce Gottlieb,Lenore K. Beitel,Lenore K. Beitel,Abbesha Nadarajah,Miltiadis Paliouras,Mark Trifiro,Mark Trifiro +6 more
TL;DR: For the first time, a disconnect within the AIS phenotype–genotype relationship among the authors' own patient database is reported, in that over 40% of patients with a classic complete AIS or partial AIS phenotypes did not appear to have a mutation in their AR gene.
Journal ArticleDOI
The androgen receptor gene mutations database (ARDB): 2004 update.
Bruce Gottlieb,Bruce Gottlieb,Lenore K. Beitel,Lenore K. Beitel,Jian Hui Wu,Mark Trifiro,Mark Trifiro +6 more
TL;DR: The current version of the androgen receptor (AR) gene mutations database is described, and a 3D model of the AR ligand‐binding domain (AR LBD) has been added to give a better understanding of gene structure–function relationships.
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The Androgen Receptor Gene Mutations Database
Bruce Gottlieb,Heikki Lehväslaiho,Lenore K. Beitel,Rose Lumbroso,Leonard Pinsky,Mark Trifiro,Mark Trifiro +6 more
TL;DR: The current version of the androgen receptor (AR) gene mutations database is described, and the contribution of CpG sites to the multiplicity of reports of the same mutation in different families is examined.
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Interactions between androgen and estrogen receptors and the effects on their transactivational properties.
Valerie Panet-Raymond,Bruce Gottlieb,Bruce Gottlieb,Bruce Gottlieb,Lenore K. Beitel,Leonard Pinsky,Mark Trifiro,Mark Trifiro +7 more
TL;DR: It is demonstrated that the androgen receptor (AR) and estrogen receptor-alpha (ERalpha) can interact directly using the yeast and mammalian two-hybrid systems and the functional consequences of such interaction are demonstrated.
Journal ArticleDOI
Estrogen and Androgen Protection of Human Neurons against Intracellular Amyloid β1-42 Toxicity through Heat Shock Protein 70
Yan Zhang,Nathalie Champagne,Lenore K. Beitel,Cynthia G. Goodyer,Mark Trifiro,Andréa C. LeBlanc +5 more
TL;DR: Estrogen and androgens protect human neurons against iAβ1-42 toxicity by increasing the levels of heat shock protein 70 (Hsp70) in testosterone- and estrogen-treated human neurons.