Showing papers in "Molecular and Cellular Endocrinology in 2000"

TL;DR: High abortion and malformation rates related to the different stages of oocyte maturation at the time of exposure to chemotherapy were demonstrated, which should be taken into account when considering the use of IVF and embryo cryopreservation following chemotherapy treatment in cancer patients.

TL;DR: Members of the TGFbeta superfamily are potent regulators of cell proliferation and differentiation in a number of organ systems, and three members, growth differentiation factor 9 (GDF-9), bone morphogenetic protein 15 (BMP-15) and BMP-6 are expressed by the oocytes and may mediate effects attributed to the oocyte.

TL;DR: Although a graphical abstract is optional, its use is encouraged as it draws more attention to the online article and authors can make use of Elsevier's Illustration Services to ensure the best presentation of their images.

TL;DR: A more refined model with an exponential rate of follicle loss that changes gradually throughout life leads to a distribution of age at menopause, corresponding to follicle numbers falling below a critical threshold, that shows quite remarkable agreement with independent data on menopausal ages of American women.

TL;DR: The development of the germ cell lineage, up until about the time of birth, then the various somatic components of the gonad and finally the interactions that are known to occur between lineages are described.

TL;DR: The results suggest that if comparable results could be achieved by autografting, a patient's fertility should be safeguarded from cytotoxic treatment.

TL;DR: Grafted ovarian cortical pieces beneath the chick CAM provides an experimental system in which follicles remain at the primordial stage in a readily accessible environment and which, thus, may be used to study potential regulators of the initiation of follicle growth.

TL;DR: There is now an emerging consensus that osteocytes modulate signals arising from mechanical loading and so direct the appearance and disappearance of bone tissue at the microscopic level, which allows bone as an organ both to grow and to adapt efficiently to the body's mechanical needs for strength with lightness.

TL;DR: It is demonstrated that pregnancies can also be achieved when frozen eggs are fertilized by testicular and epididymal sperm and a program of oocyte cryopreservation for oncological patients has been initiated in this centre.

TL;DR: It is demonstrated that the androgen receptor (AR) and estrogen receptor-alpha (ERalpha) can interact directly using the yeast and mammalian two-hybrid systems and the functional consequences of such interaction are demonstrated.

TL;DR: Anovulation in women with polycystic ovary syndrome (PCOS) is characterised by arrested growth of antral follicles and a relative lack of FSH may contribute to the persistence of anovulation but is unlikely to be a major cause of it.

TL;DR: The results suggest that alpha2-HSG, by interacting with IR, specifically inhibits insulin-stimulated IR autophosphorylation and may play a physiological role in the regulation of insulin signaling.

TL;DR: Using fetal sheep as the animal model, aspects of ovarian development related to follicular formation are reviewed and the identity of growth and paracrine factors which might be involved in this process are reported on.

TL;DR: Testosterone substitution is necessary in all hypogonadal patients, because androgen deficiency causes slight anemia, changes in coagulation parameters, decreased bone density, muscle atrophy, regression of sexual function and alterations in mood and cognitive abilities.

TL;DR: In human endometrium, apoptosis occurs predominantly in the late secretory and menstrual phases, and is related to alterations in the expression of Bcl-2 and Bax.

TL;DR: The data suggest that SCF supports germ cell survival during spermatogenesis by up-regulating pro-survival B cl-2 family proteins, Bcl-w and BCl-xL, and down-regulate pro-apoptosis Bcl/xL proteins, e.g. Bax.

TL;DR: It is demonstrated that this stable transfectant provides an accurate tool for studying wild-type human AR activation and its regulation by androgens and antiandrogens in a human prostatic epithelial cell, which is routinely available and remains androgen-responsive in vitro.

TL;DR: The cloning and characterization of a TR beta1 cDNA from zebrafish showed that there is a single genomic locus for the TR beta gene, while the TR alpha gene potentially has two loci, and multiple TR alpha and TR beta transcripts were detected in adult tissues.

TL;DR: It appears that formation and development of mammalian follicles requires the concerted action of genes originally thought to be only involved in cell differentiation/survival of neuronal cells, and genes that may control the growth, differentiation, and cell-cell interactions of somatic and germ cells in the ovary.

TL;DR: A culture system was established that utilizes these complexes to assess mechanisms promoting nuclear, cytoplasmic and genomic maturation in mammalian oocytes to hypothesized that oocytes control the differentiation of these cells in order to promote intercellular signaling essential for the acquisition of competence to undergo normal embryogenesis.

TL;DR: GDF-9 functions as an oocyte-secreted growth and differentiation factor during early and late folliculogenesis and at ovulation to regulate several key somatic cell functions essential for female reproduction.

TL;DR: The conserved deduced protein sequence and expression pattern of StAR transcripts in chicken and zebrafish tissues, strongly suggest that StAR is also involved in the regulation of steroidogenesis in nonmammalian vertebrates.

TL;DR: It is concluded that ERβ is the predominant ER subtype in the epithelium of adult male rat accessory sex glands and the lower urinary tract of both males and females, as well as in the prostatic neural plexus regulating the function of theLower urinary tract in males, while ERα is present only in the stromal compartment of distinct sites.

TL;DR: The cloning of the full-length chicken leptin receptor (CLEPR) cDNA is reported, which is the first non-mammalian cloning of a LEPR gene, and shows tight conservation of most previously characterized LEPR motifs and essential tyrosine residues.

TL;DR: Strong evidence is provided that sgk is an aldosterone-induced gene in vivo in a mammalian system and the responses to both adrenalectomy and carbenoxolone sodium treatment suggest that the observed responses to corticosteroids can occur in the physiological range of endogenous circulating cortICosteroids.

TL;DR: In double mutant XY-mice lacking INSL3 and a functional androgen receptor, it was demonstrated that both are essential for establishment of the sexual dimorphic position of the gonads through regulation of gubernaculum development and regression of the cranial suspensory ligament (CSL) during fetal life.

TL;DR: It is demonstrated that 1,25(OH)2D3, in addition to decreasing proliferation of tumor cells, can also inhibit prostate cancer cell invasion through modulation of select cell surface adhesion molecules.

TL;DR: In the primate ovary, androgens promote oocyte insulin-like growth factor (IGF) I expression as well as initiation of follicle development and the decrease in IGFBPs participates in the increase in IGF bioavailability, leading to a further amplification of FSH action.

TL;DR: Observations indicate that glucocorticoids are powerful inhibitors of the UCP1 gene response to adrenergic stimulation acting at transcriptional level, and provide further evidence for a global inhibitory effect of glucoc Corticoids on BAT thermogenesis.

TL;DR: A number of clinical trials have compared the efficacy of recombinant human FSH (r-hFSH) and urinary FSH in women undergoing assisted reproductive technologies (ART) as mentioned in this paper.