L
Leo K.Y. So
Researcher at City University of Hong Kong
Publications - 10
Citations - 508
Leo K.Y. So is an academic researcher from City University of Hong Kong. The author has contributed to research in topics: Xenobiotic & Genotype. The author has an hindex of 7, co-authored 10 publications receiving 477 citations. Previous affiliations of Leo K.Y. So include University of Hong Kong & Pamela Youde Nethersole Eastern Hospital.
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Journal ArticleDOI
3C-SiC nanocrystals as fluorescent biological labels.
TL;DR: Synthesis of SiC nanoparticles with diameters of tens of nanometers shows emission in the blue-to-UV range and the observed emissions can be ascribed to some surface or defect states in the SiC nanostructures.
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A bioaccumulative cyclometalated platinum(II) complex with two-photon-induced emission for live cell imaging.
Chi Kin Koo,Ka-Leung Wong,Cornelia Wing Yin Man,Yun Wah Lam,Leo K.Y. So,Hoi Lam Tam,Sai Wah Tsao,Kok Wai Cheah,Kai-Chung Lau,Yangyi Yang,Jin Can Chen,Michael H.W. Lam +11 more
TL;DR: Its bioaccumulation properties enabled time-lapse imaging of the internalization process of the dye into living cells, and Cytotoxicity of [Pt(L)Cl] to both tested cell lines was low, according to MTT assays, even at loadings as high as 20 times the dose concentration for imaging for 6 h.
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CHD5 is down-regulated through promoter hypermethylation in gastric cancer.
TL;DR: CHD5 was a TSG epigenetically down-regulated in gastric cancer and significantly restored after pharmacological demethylation, leading to a significant growth inhibition.
Journal ArticleDOI
A Triphenylphosphonium-Functionalised Cyclometalated Platinum(II) Complex as a Nucleolus-Specific Two-Photon Molecular Dye
Chi Kin Koo,Leo K.Y. So,Ka-Leung Wong,Yu Man Ho,Yun Wah Lam,Michael H.W. Lam,Kwok Wai Cheah,Chopen Chan Wut Cheng,Wai Ming Kwok +8 more
TL;DR: The organelle-specific labelling and two-photon-induced luminescent properties of [Pt(L(3))Cl](+) renders it a useful nuclear dye for the 3-dimensional reconstruction of optical sections of thick tissues, for example, mouse ileum tissues, by multiphoton confocal microscopy.
Journal ArticleDOI
Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics.
Judith C.W. Mak,S. P. Ho,Helen C.M. Leung,A. H. K. Cheung,B. K. W. Law,Leo K.Y. So,Johnny W.M. Chan,Chi-Hung Chau,W. K. Lam,Mary S.M. Ip,Moira Chan-Yeung,Moira Chan-Yeung +11 more
TL;DR: This data indicates that suppression of glutathione S‐transferases in the absence of a specific carrier gene results in down-regulation in the expression of GST genes, which is a major cause of asthma.