L
Leo R. Zacharski
Researcher at Dartmouth College
Publications - 121
Citations - 3998
Leo R. Zacharski is an academic researcher from Dartmouth College. The author has contributed to research in topics: Tissue factor & Cancer. The author has an hindex of 35, co-authored 121 publications receiving 3903 citations. Previous affiliations of Leo R. Zacharski include University of Nevada, Reno & University of Connecticut.
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Journal ArticleDOI
Effect of warfarin anticoagulation on survival in carcinoma of the lung, colon, head and neck, and prostate. Final report of VA Cooperative Study #75.
Leo R. Zacharski,William G. Henderson,Frederick R. Rickles,Walter B. Forman,C. J. Cornell,A. Jackson Forcier,Richard L. Edwards,Elwood Headley,Sang‐Hee ‐H Kim,J. F. Ódonnell,J. F. Ódonnell,Robert O'Dell,Karl Tornyos,Hau C. Kwaan +13 more
TL;DR: The results suggest that warfarin, as a single anticoagulant agent, may favorably modify the course of some, but not all, types of human malignancy, among which is small cell carcinoma of the lung.
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Effect of Warfarin on Survival in Small Cell Carcinoma of the Lung: Veterans Administration Study No. 75
Leo R. Zacharski,William G. Henderson,Frederick R. Rickles,Walter B. Forman,Cornelius J. Cornell,R. Jackson Forcier,Richard L. Edwards,Elwood Headley,Sang-Hee Kim,Joseph R. O'Donnell,Robert O'Dell,Karl Tornyos,Hau C. Kwaan +12 more
TL;DR: The results suggest that warfarin may be useful in the treatment of SCCL and also support the hypothesis that the blood coagulation mechanism may be involved in the growth and spread of cancer in man.
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Transformation and motility of human platelets: details of the shape change and release reaction observed by optical and electron microscopy.
TL;DR: It is suggested that high extinction DIC microscope examination may become a rapid and useful method of studying congenital and acquired platelet disorders.
Journal ArticleDOI
Heparin and Cancer
TL;DR: The improved cancer outcome could not be attributed to prevention of VTE in any of the studies; therefore, it is reasonable to hypothesize that a beneficial effect of heparin may be mediated by mechanisms independent of anticoagulation.
Journal ArticleDOI
Pathways of coagulation/fibrinolysis activation in malignancy.
Leo R. Zacharski,Marek Z. Wojtukiewicz,Vincenzo Costantini,Deborah L. Ornstein,Vincent A. Memoli +4 more
TL;DR: A preliminary classification of tumors is proposed based on interactions between malignancy and coagulation or fibrinolysis reactions in humans and indicates the prospect that imaginative approaches to cancer treatment may be devised that are not only relatively nontoxic and low cost, but also effective.