Journal ArticleDOI
Effect of Warfarin on Survival in Small Cell Carcinoma of the Lung: Veterans Administration Study No. 75
Leo R. Zacharski,William G. Henderson,Frederick R. Rickles,Walter B. Forman,Cornelius J. Cornell,R. Jackson Forcier,Richard L. Edwards,Elwood Headley,Sang-Hee Kim,Joseph R. O'Donnell,Robert O'Dell,Karl Tornyos,Hau C. Kwaan +12 more
TLDR
The results suggest that warfarin may be useful in the treatment of SCCL and also support the hypothesis that the blood coagulation mechanism may be involved in the growth and spread of cancer in man.Abstract:
In a controlled, randomized study, survival of patients with small cell carcinoma of the lung (SCCL) was prolonged on addition of warfarin sodium to combination chemotherapy plus radiation therapy. Median survival for 25 control patients was 24 weeks and for 25 warfarin-treated patients was 50 weeks. This difference could not be accounted for by differences between groups in performance status, extent of disease, age, or sex. The survival advantage associated with warfarin administration was observed both for patients with extensive disease and for those who failed to achieve complete or partial remission. The warfarin-treated group also demonstrated a significantly increased time to first evidence of disease progression. These results suggest that warfarin may be useful in the treatment of SCCL and also support the hypothesis that the blood coagulation mechanism may be involved in the growth and spread of cancer in man. ( JAMA 1981;245:831-835)read more
Citations
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Journal ArticleDOI
Double-blind randomised trial of very-low-dose warfarin for prevention of thromboembolism in stage IV breast cancer
Mitch Levine,Jack Hirsh,Andrew Arnold,Michael Gent,Vivien H.C. Bramwell,Kathleen I. Pritchard,David J. Stewart,David Warr,Pamela J. Goodwin,M. Samosh,Anna Falanga +10 more
TL;DR: Very-low-dose warfarin is a safe and effective method for prevention of thromboembolism in patients with metastatic breast cancer who are receiving chemotherapy.
Journal ArticleDOI
Randomized Comparison of Low Molecular Weight Heparin and Coumarin Derivatives on the Survival of Patients With Cancer and Venous Thromboembolism
Agnes Y.Y. Lee,Frederick R. Rickles,Jim A. Julian,Michael Gent,Ross I. Baker,Chris Bowden,Ajay K. Kakkar,Martin H. Prins,Mark Levine +8 more
TL;DR: The use of dalteparin relative to coumarin derivatives was associated with improved survival in patients with solid tumors who did not have metastatic disease at the time of an acute venous thromboembolic event.
Journal ArticleDOI
Incidence of cancer after prophylaxis with warfarin against recurrent venous thromboembolism
Sam Schulman,Per Lindmarker +1 more
TL;DR: The risk of newly diagnosed cancer after a first episode of venous thromboembolism is elevated during at least the following two years, and the risk seems to be lower among patients treated with oral anticoagulants for six months than among those treated for six weeks.
Journal ArticleDOI
Effect of warfarin anticoagulation on survival in carcinoma of the lung, colon, head and neck, and prostate. Final report of VA Cooperative Study #75.
Leo R. Zacharski,William G. Henderson,Frederick R. Rickles,Walter B. Forman,C. J. Cornell,A. Jackson Forcier,Richard L. Edwards,Elwood Headley,Sang‐Hee ‐H Kim,J. F. Ódonnell,J. F. Ódonnell,Robert O'Dell,Karl Tornyos,Hau C. Kwaan +13 more
TL;DR: The results suggest that warfarin, as a single anticoagulant agent, may favorably modify the course of some, but not all, types of human malignancy, among which is small cell carcinoma of the lung.
Journal ArticleDOI
Fibrin as a component of the tumor stroma: origins and biological significance
Harold F. Dvorak,Harold F. Dvorak,Donald R. Senger,Donald R. Senger,Ann M. Dvorak,Ann M. Dvorak +5 more
TL;DR: The current status of fibrin's role in the biology of tumor growth is reviewed, considering such important possiblities as a barrier function to the immune response and possible roles in angiogenesis, desmoplasia, and metastasis.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
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A generalized Wilcoxon test for comparing arbitrarily singly-censored samples
TL;DR: Some comparisons are made for five cases of varying degrees of censoring and tying between probabilities from the exact test and those from the proposed test and these suggest the test is appropriate under certain conditions when the sample size is five in each group.
Journal ArticleDOI
Small-Cell Carcinoma of the Lung: Combined Chemotherapy and Radiation: A Southwest Oncology Group Study
R. B. Livingston,T. N. Moore,L. Heilbrun,R. Bottomley,Daniel E. Lehane,Saul E. Rivkin,T. Thigpen +6 more
TL;DR: Chemotherapy (doxorubicin, cyclophosphamide, and vincristine) was given in a sequential fashion with radiation of the primary tumor and brain to 358 patients with small-cell lung carcinoma and whole-brain radiation was effective in preventing isolated relapse at that site.
Journal ArticleDOI
A randomized combined modality trial in small cell carcinoma of the lung comparison of combination chemotherapy‐radiation therapy versus cyclophosphamide‐radiation therapy effects of maintenance chemotherapy and prophylactic whole brain irradiation
L. Herbert Maurer,Marchant Tulloh,Raymond B. Weiss,Johannes Blom,Louis A. Leone,Oliver Glidewell,Thomas F. Pajak +6 more
TL;DR: Survival, frequency of response and site of relapse were different in patients with limited disease when compared with disease spread beyond these sites (extensive disease) (ED), and no survival advantage was seen in LD when combination chemotherapy was employed, although the frequency of complete remission was greater with three drugs than with one or two drugs.
Journal ArticleDOI
Prophylactic cranial irradiation in small cell carcinoma of the lung: A Randomized Study
Don V. Jackson,Frederick Richards,M. Robert Cooper,Carolyn Ferree,Hyman B. Muss,Douglas R. White,Charles L. Spurr +6 more
TL;DR: Although PCI did not improve response rate or survival, brain metastasis with its attendant neurologic complications was effectively prevented and was the cause of major neurologic disability in each.