L
Leonard M. Anderson
Researcher at Morehouse School of Medicine
Publications - 22
Citations - 763
Leonard M. Anderson is an academic researcher from Morehouse School of Medicine. The author has contributed to research in topics: Genetic enhancement & Endothelial stem cell. The author has an hindex of 13, co-authored 22 publications receiving 702 citations. Previous affiliations of Leonard M. Anderson include Brigham and Women's Hospital & Northwestern University.
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Journal ArticleDOI
MicroRNA-27 (miR-27) Targets Prohibitin and Impairs Adipocyte Differentiation and Mitochondrial Function in Human Adipose-derived Stem Cells
Ting Kang,Ting Kang,Wan Lu,Wei Xu,Leonard M. Anderson,Methode Bacanamwo,Winston E. Thompson,Y. Eugene Chen,Dong Liu +8 more
TL;DR: The data suggest that miR-27 is an anti-adipogenic microRNA partly by targeting PHB and impairing mitochondrial function, and may provide a new therapeutic strategy for the treatment of obesity.
Journal ArticleDOI
Liver X receptors α and β regulate renin expression in vivo
Fulvio Morello,Rudolf A. de Boer,Rudolf A. de Boer,Knut R. Steffensen,Massimiliano Gnecchi,Massimiliano Gnecchi,Jeffrey W. Chisholm,Frans Boomsma,Leonard M. Anderson,Richard M. Lawn,Jan-Åke Gustafsson,Marco Lopez-Ilasaca,Richard E. Pratt,Richard E. Pratt,Victor J. Dzau,Victor J. Dzau,Victor J. Dzau +16 more
TL;DR: It is shown that LXR (alpha) and LXR(beta) regulate renin expression in vivo by directly interacting with the renin promoter and that the cAMP/LXR(alpha) signaling pathway is required for the adrenergic control of the ren in-angiotensin system.
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Targeted expression of toxic genes directed by pituitary hormone promoters: a potential strategy for adenovirus-mediated gene therapy of pituitary tumors.
TL;DR: It is suggested that adenoviral vectors carrying human pituitsary gland specific promoters may be useful for developing gene therapy strategies for the treatment of pituitary adenomas.
Journal ArticleDOI
Gene expression following acute morphine administration.
Alexander V Loguinov,Leonard M. Anderson,Gregory Crosby,Gregory Crosby,Rustam Yukhananov,Rustam Yukhananov +5 more
TL;DR: Data indicate that microarray analysis by itself is useful in describing the effect of well-known substances on the nervous system and provides sufficient information to propose a potentially novel pathway mediating its activity.
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Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer.
Leonard M. Anderson,Sathyamangalam Swaminathan,I. Zackon,A. K. Tajuddin,Bayar Thimmapaya,Sigmund A. Weitzman +5 more
TL;DR: Adenoviral vectors containing either the beta-galactosidase (β-gal) reporter gene or the herpes simplex thymidine kinase (HSVtk) suicide gene driven by breast tissue-specific promoters may be a feasible therapy for the treatment of human breast cancer.