W
Winston E. Thompson
Researcher at Morehouse School of Medicine
Publications - 76
Citations - 2728
Winston E. Thompson is an academic researcher from Morehouse School of Medicine. The author has contributed to research in topics: Prohibitin & Cellular differentiation. The author has an hindex of 29, co-authored 66 publications receiving 2312 citations.
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Journal ArticleDOI
Ubiquitination of prohibitin in mammalian sperm mitochondria: possible roles in the regulation of mitochondrial inheritance and sperm quality control.
TL;DR: The results of the present study suggest that prohibitin is one of the ubiquitinated substrates that makes the sperm mitochondria recognizable by the egg's ubiquitin-proteasome dependent proteolytic machinery after fertilization and most likely facilitates the marking of defective spermatozoa in the epididymis for degradation.
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Chemoresistance in human ovarian cancer: the role of apoptotic regulators
Michael Fraser,Brendan M. Leung,Arezu Jahani-Asl,Xiaojuan Yan,Winston E. Thompson,Benjamin K. Tsang +5 more
TL;DR: The biochemical pathways believed to promote cell survival and how they modulate chemosensitivity are discussed and some new research directions by which the fundamental mechanisms of chemoresistance can be elucidated are concluded.
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Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31
Ting Kang,Tia M. Jones,Clayton Naddell,Methode Bacanamwo,John W. Calvert,Winston E. Thompson,Vincent C. Bond,Y. Eugene Chen,Dong Liu +8 more
TL;DR: It is observed for the first time that MVs were released from adipose‐derived stem cells (ASCs) and were able to increase the migration and tube formation of human umbilical vein endothelial cells (HUVECs) and the level of microRNA‐31 (miR‐31) in MVs was notably elevated upon EDM‐preconditioning of MV‐donor ASCs.
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Gonadotropin and intra-ovarian signals regulating follicle development and atresia: the delicate balance between life and death.
Jesse Craig,Makoto Orisaka,Hongmei Wang,Sanae Orisaka,Winston E. Thompson,Cheng Zhu,Fumikazu Kotsuji,Benjamin K. Tsang +7 more
TL;DR: The intracellular protein prohibitin appears to have a dual role during folliculogenesis; acting as a cell survival factor in undifferentiated cells, and as a pro-apoptotic factor following differentiation.
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MicroRNA-27 (miR-27) Targets Prohibitin and Impairs Adipocyte Differentiation and Mitochondrial Function in Human Adipose-derived Stem Cells
Ting Kang,Ting Kang,Wan Lu,Wei Xu,Leonard M. Anderson,Methode Bacanamwo,Winston E. Thompson,Y. Eugene Chen,Dong Liu +8 more
TL;DR: The data suggest that miR-27 is an anti-adipogenic microRNA partly by targeting PHB and impairing mitochondrial function, and may provide a new therapeutic strategy for the treatment of obesity.