M
Marco Lopez-Ilasaca
Researcher at Brigham and Women's Hospital
Publications - 22
Citations - 2195
Marco Lopez-Ilasaca is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Angiotensin II & Angiotensin II receptor type 1. The author has an hindex of 17, co-authored 22 publications receiving 2101 citations.
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Journal ArticleDOI
Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation.
Nicolas Noiseux,Massimiliano Gnecchi,Marco Lopez-Ilasaca,Lunan Zhang,Scott D. Solomon,Arjun Deb,Victor J. Dzau,Richard E. Pratt +7 more
TL;DR: MSC-Akt improved early repair despite transient engraftment, low levels of cellular fusion, and differentiation, and further confirm the recently reported data that early paracrine mechanisms mediated by MSC are responsible for enhancing the survival of existing myocytes and that Akt could alter the secretion of various cytokines and growth factors.
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N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.
Scott B. Snapper,Scott B. Snapper,Fuminao Takeshima,Inés M. Antón,Inés M. Antón,Ching-Hui Liu,Ching-Hui Liu,Sheila M. Thomas,Sheila M. Thomas,Deanna Nguyen,Darryll D. Dudley,Hunter B. Fraser,Daniel L. Purich,Marco Lopez-Ilasaca,Christoph Klein,Christoph Klein,Laurie Davidson,Roderick T. Bronson,Richard C. Mulligan,Richard C. Mulligan,Frederick S. Southwick,Raif S. Geha,Raif S. Geha,Marcia B. Goldberg,Fred S. Rosen,Fred S. Rosen,John H. Hartwig,John H. Hartwig,Frederick W. Alt,Frederick W. Alt,Frederick W. Alt +30 more
TL;DR: A crucial and non-redundant role for N-WASP in murine embryogenesis and in the actin-based motility of certain pathogens but not in the general formation of actin -containing structures is implied.
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Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells.
Deling Kong,Luis G. Melo,Abeel A. Mangi,Lunan Zhang,Marco Lopez-Ilasaca,Mark A. Perrella,Chong C. Liew,Richard E. Pratt,Victor J. Dzau +8 more
TL;DR: It is concluded that transplantation of autologous EPCs overexpressing eNOS in injured vessels enhances the vasculoprotective properties of the reconstituted endothelium, leading to inhibition of neointimal hyperplasia.
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Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10.
TL;DR: The results suggest that adiponectin triggers a multifaceted response in human macrophages by inducing the expression of various anti-inflammatory proteins that act at different levels in concert to suppress macrophage activation.
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The Angiotensin II Type I Receptor-associated Protein, ATRAP, Is a Transmembrane Protein and a Modulator of Angiotensin II Signaling
TL;DR: ATRAP is characterized as a transmembrane protein localized in intracellular trafficking vesicles and plasma membrane that functions as a modulator of angiotensin II-induced signal transduction and a moderate decrease in the generation of inositol lipids.