Gregory Crosby

TL;DR: The working group recommends that ‘perioperative neurocognitive disorders’ be used as an overarching term for cognitive impairment identified in the preoperative or postoperative period as well as two major classification guidelines used outside of anaesthesia and surgery.

TL;DR: The working group recommends that ‘perioperative neurocognitive disorders’ be used as an overarching term for cognitive impairment identified in the preoperative or postoperative period as well as two major classification guidelines used outside of anaesthesia and surgery.

TL;DR: RAM performance is altered after general anesthesia for longer than predicted by the pharmacology of the drugs used, which, by inference, suggests a long-term deficit in learning/memory.

TL;DR: A clinically relevant concentration of isoflurane induces apoptosis, alters APP processing, and increases A&bgr; production in a human neuroglioma cell line, which may have implications for use of this anesthetic agent in individuals with excessive levels of cerebral amyloid and elderly patients at increased risk for postoperative cognitive dysfunction.

TL;DR: It is demonstrated that general anesthesia with isoflurane and nitrous oxide improves the memory performance on an established spatial memory task in young rats, but in aged rats it attenuates the improvement in performance that otherwise occurs with repeated testing.