J
John C. Schimenti
Researcher at Cornell University
Publications - 189
Citations - 11200
John C. Schimenti is an academic researcher from Cornell University. The author has contributed to research in topics: Meiosis & Gene. The author has an hindex of 56, co-authored 181 publications receiving 9878 citations. Previous affiliations of John C. Schimenti include Princeton University.
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Journal ArticleDOI
Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog.
Douglas L. Pittman,John Cobb,Kerry J. Schimenti,Lawriston A. Wilson,Deborah M. Cooper,Ember Brignull,Mary Ann Handel,John C. Schimenti +7 more
TL;DR: A null mutation is generated in the Dmc1 gene in mice and it is shown that homozygous mutant males and females are sterile with arrest of gametogenesis in the first meiotic prophase.
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Genetics of mammalian meiosis: regulation, dynamics and impact on fertility
TL;DR: An understanding of the regulation of meiosis, coupled with advances in genomics, may ultimately allow us to diagnose the causes of meiotic-based infertilities, more wisely apply assisted reproductive technologies, and derive functional germ cells.
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Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly.
Douglas B. Gould,F. Campbell Phalan,Guido J. Breedveld,Saskia E. van Mil,Richard S. Smith,John C. Schimenti,Umberto Aguglia,Marjo S. van der Knaap,Peter Heutink,Simon W. M. John,Simon W. M. John +10 more
TL;DR: It is proposed that Col4a1 mutations conspire with environmental trauma in causing porencephaly, and shows that vascular defects are caused by a semidominant mutation in the procollagen type IV α 1 gene in mice, which inhibits the secretion of mutant and normal type IV collagen.
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A Mouse Speciation Gene Encodes a Meiotic Histone H3 Methyltransferase
TL;DR: Identification of a vertebrate hybrid sterility gene reveals a role for epigenetics in speciation and opens a window to a hybrid sterilities gene network and rescued infertility in male hybrids with bacterial artificial chromosomes carrying Prdm9.
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An Ancient Transcription Factor Initiates the Burst of piRNA Production during Early Meiosis in Mouse Testes
Xin Zhiguo Li,Christian K. Roy,Xianjun Dong,Ewelina Bolcun-Filas,Jie Wang,Bo W. Han,Jia Xu,Melissa J. Moore,John C. Schimenti,Zhiping Weng,Phillip D. Zamore +10 more
TL;DR: It is shown that the transcription factor A-MYB initiates pachytene piRNA production and regulation of piRNA pathway proteins and piRNA genes creates a coherent feedforward loop that ensures the robust accumulation of pachyTene piRNAs.