Leonid P. Churilov

TL;DR: The pathologic features of lymphocytic infiltration, especially of T cells, and follicular destruction are the histological hallmark of autoimmune thyroiditis, that lead to gradual atrophy and fibrosis.

TL;DR: It is suggested that based on the similarities of the immune dysfunction in the severe cases of different respiratory viral infections, some lessons from the immunomodulatory therapy of COVID-19 could be applied for some cases of severe influenza infection and probably for some future outbreaks of novel severe respiratory virus infections.

TL;DR: This review attempts an integral analysis of currently available information suggesting an autoimmune genesis of sarcoidosis and is divided into four categories: the evaluation of clinical signs described both in patients with sarcoIDosis and “classic” autoimmune diseases, the role of triggering factors in the development of sarCOidosis, the presence of immunogenic susceptibility in theDevelopment of the disease, and the analysis of cellular and humoral immune responses in sarcoids.

TL;DR: Evidence regarding the role of autoimmunity in these four syndromes with respect to immunogenetics, autoimmune co-morbidities, alteration in immune cell subsets, production of autoantibodies and presentation in animal models is summarized.

TL;DR: The studies established to date suggest that autoantibodies not only regulate cancer progression but also promise to be valuable instruments in oncological diagnosis and therapy.