Institution
Gentofte Hospital
Healthcare•Copenhagen, Denmark•
About: Gentofte Hospital is a healthcare organization based out in Copenhagen, Denmark. It is known for research contribution in the topics: Population & Cohort study. The organization has 2384 authors who have published 2763 publications receiving 78328 citations. The organization is also known as: Copenhagen University Hospital Gentofte.
Papers published on a yearly basis
Papers
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TL;DR: Although there was a trend towards greater reduction in risk of death or readmission for heart failure in patients with lower ejection fractions, benefit was apparent over the range examined.
1,479 citations
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TL;DR: In this trial, prophylactic ICD implantation in patients with symptomatic systolic heart failure not caused by coronary artery disease was not associated with a significantly lower long-term rate of death from any cause than was usual clinical care.
Abstract: BackgroundThe benefit of an implantable cardioverter–defibrillator (ICD) in patients with symptomatic systolic heart failure caused by coronary artery disease has been well documented. However, the evidence for a benefit of prophylactic ICDs in patients with systolic heart failure that is not due to coronary artery disease has been based primarily on subgroup analyses. The management of heart failure has improved since the landmark ICD trials, and many patients now receive cardiac resynchronization therapy (CRT). MethodsIn a randomized, controlled trial, 556 patients with symptomatic systolic heart failure (left ventricular ejection fraction, ≤35%) not caused by coronary artery disease were assigned to receive an ICD, and 560 patients were assigned to receive usual clinical care (control group). In both groups, 58% of the patients received CRT. The primary outcome of the trial was death from any cause. The secondary outcomes were sudden cardiac death and cardiovascular death. ResultsAfter a median follow-...
1,239 citations
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TL;DR: Pembrolizumab led to significantly longer progression-free survival than chemotherapy when received as first-line therapy for MSI-H-dMMR metastatic colorectal cancer, with fewer treatment-related adverse events.
Abstract: Background Programmed death 1 (PD-1) blockade has clinical benefit in microsatellite-instability–high (MSI-H) or mismatch-repair–deficient (dMMR) tumors after previous therapy. The efficac...
1,169 citations
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TL;DR: The increase of HL-A8 in insulin-dependent diabetes, Graves' disease, and idiopathic Addison's disease is suggestive of a common pathogenesis of these endocrine autoimmune conditions.
705 citations
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TL;DR: A simple model for migraine attacks is suggested: A pathological disturbance in one cerebral hemisphere causes the aura symptoms and after a time delay, it also causes the headache by stimulating local vascular nociceptors.
Abstract: Ten years of study has resulted in considerable but fragmented knowledge about regional cerebral blood flow in migraine with aura (classic migraine). In the present study, the number of repeatedly studied patients (n = 63) was large enough to determine statistically significant sequences of events and statistically significant spatial relations. The first observable event was a decrease of regional cerebral blood flow posteriorly in one cerebral hemisphere. Further development of this pathological process was accompanied by the aura symptoms. Thereafter headache occurred while regional cerebral blood flow remained decreased. During the headache phase, regional cerebral blood flow gradually changed from abnormally low to abnormally high without apparent change in headache. In some patients headache disappeared while regional cerebral blood flow remained increased. Although regional cerebral blood flow reduction and aura symptoms in the great majority of patients were unilateral, one-third had bilateral headache. Unilateral headache usually localized to the side on which regional cerebral blood flow was reduced and from which the aura symptoms originated (i.e., aura symptoms were perceived to occur contralaterally but presumably originated in the hypoperfused hemisphere). Our results suggest a simple model for migraine attacks: A pathological disturbance in one cerebral hemisphere causes the aura symptoms and after a time delay, it also causes the headache by stimulating local vascular nociceptors. Bilateral headache caused by a unilateral cerebral disturbance may be explained by recent neuroanatomical and neurophysiological findings.
552 citations
Authors
Showing all 2400 results
Name | H-index | Papers | Citations |
---|---|---|---|
Børge G. Nordestgaard | 147 | 1047 | 95530 |
Torben Jørgensen | 135 | 883 | 86822 |
Bente Klarlund Pedersen | 134 | 689 | 72177 |
Henrik Kehlet | 130 | 1069 | 76338 |
Jes Olesen | 124 | 808 | 79687 |
Henrik Toft Sørensen | 120 | 1591 | 74943 |
Arne Astrup | 114 | 866 | 68877 |
Lars Køber | 114 | 1155 | 77298 |
Christian Torp-Pedersen | 110 | 1164 | 58121 |
Jørgen Vestbo | 105 | 643 | 71770 |
Hans Bisgaard | 99 | 517 | 35563 |
Anne Tybjærg-Hansen | 97 | 398 | 41244 |
Steffen Loft | 90 | 486 | 28726 |
Peter Aaby | 85 | 640 | 28101 |
Niels H. Secher | 84 | 584 | 26201 |