L
Leonie K. Heilbronn
Researcher at University of Adelaide
Publications - 154
Citations - 11423
Leonie K. Heilbronn is an academic researcher from University of Adelaide. The author has contributed to research in topics: Insulin resistance & Type 2 diabetes. The author has an hindex of 47, co-authored 138 publications receiving 9947 citations. Previous affiliations of Leonie K. Heilbronn include Louisiana State University & Garvan Institute of Medical Research.
Papers
More filters
Journal ArticleDOI
Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial.
Leonie K. Heilbronn,Lilian de Jonge,Madlyn I. Frisard,James P. DeLany,D. Enette Larson-Meyer,Jennifer Rood,Tuong Nguyen,Corby K. Martin,Julia Volaufova,Marlene M. Most,Frank L. Greenway,Steven R. Smith,Walter A. Deutsch,Donald A. Williamson,Eric Ravussin +14 more
TL;DR: The findings suggest that 2 biomarkers of longevity (fasting insulin level and body temperature) are decreased by prolonged calorie restriction in humans and support the theory that metabolic rate is reduced beyond the level expected from reduced metabolic body mass.
Journal ArticleDOI
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans.
Anthony E. Civitarese,Stacy Carling,Leonie K. Heilbronn,Mathew H Hulver,Barbara Ukropcova,Walter A. Deutsch,Steven R. Smith,Eric Ravussin +7 more
TL;DR: The observed increase in muscle mitochondrial DNA in association with a decrease in whole body oxygen consumption and DNA damage suggests that caloric restriction improves mitochondrial function in young non-obese adults.
Journal ArticleDOI
Calorie restriction and aging: review of the literature and implications for studies in humans
TL;DR: The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.
Journal ArticleDOI
Effect of Calorie Restriction With or Without Exercise on Insulin Sensitivity, β-Cell Function, Fat Cell Size, and Ectopic Lipid in Overweight Subjects
D. Enette Larson-Meyer,Leonie K. Heilbronn,Leanne M. Redman,Bradley R. Newcomer,Madlyn I. Frisard,Steve Anton,Steven R. Smith,Anthony Alfonso,Eric Ravussin +8 more
TL;DR: Large adipocytes lead to lipid deposition in visceral and hepatic tissues, promoting insulin resistance, and Calorie restriction by diet alone or with exercise reverses this trend.
Journal ArticleDOI
Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity.
TL;DR: Excitement surrounds the potential for specific inhibition of macrophage infiltration of adipose tissue via pharmacotherapy for obese patients and more particularly as adjunct therapy to improve insulin sensitivity in obese individuals with insulin resistance and overt type 2 diabetes.