Calorie restriction and aging: review of the literature and implications for studies in humans
TLDR
The absence of adequate information on the effects of good-quality, calorie-restricted diets in nonobese humans reflects the difficulties involved in conducting long-term studies in an environment so conducive to overfeeding.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2003-09-01 and is currently open access. It has received 647 citations till now. The article focuses on the topics: Calorie restriction & CALERIE.read more
Citations
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Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults
Jeremy D. Walston,Evan C. Hadley,L. Ferrucci,Jack M. Guralnik,Anne B. Newman,Stephanie A. Studenski,William B. Ershler,Tamara J. Harris,Linda Fried +8 more
TL;DR: The results of the 2004 American Geriatrics Society/National Institute on Aging conference on a Research Agenda on Frailty in Older Adults, which brought together a diverse group of clinical and basic scientists to encourage further investigation in this area are reported on.
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Is Oxidative Stress the Pathogenic Mechanism Underlying Insulin Resistance, Diabetes, and Cardiovascular Disease? The Common Soil Hypothesis Revisited
Antonio Ceriello,Enrico Motz +1 more
TL;DR: In this paper, the authors proposed a pathogenic mechanism linking insulin resistance with dysfunction of both beta cells and endothelium, eventually leading to overt diabetes and cardiovascular disease, which may also contribute to explaining why treating cardiovascular risk with drugs, such as calcium channel blockers, ACE inhibitors, AT-1 receptor antagonists, and statins, all compounds showing intracellular preventive antioxidant activity, results in the onset of new cases of diabetes possibly being reduced.
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Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.
TL;DR: The notion that multiple human SIRT proteins have evolutionarily conserved and nonconserved functions at different cellular locations is supported and the lifespan of normal human cells, in contrast to that of lower eukaryotes, cannot be manipulated by increased expression of a single SIRT protein.
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Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species.
TL;DR: The roles of cellular endogenous antioxidant systems as well as natural anti-oxidative compounds in several human diseases caused by ROS are summarized in order to illustrate the vital role of antioxidants in prevention against oxidative stress.
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Calorie restriction, SIRT1 and metabolism: understanding longevity
Laura Bordone,Leonard Guarente +1 more
TL;DR: Recent findings that are beginning to clarify the mechanisms by which CR results in longevity and robust health, which might open new avenues of therapy for diseases of ageing are summarized.
References
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Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
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Physical Fitness and All-Cause Mortality: A Prospective Study of Healthy Men and Women
Steven N. Blair,Harold W. Kohl,Ralph S. Paffenbarger,Debra G. Clark,Kenneth H. Cooper,Larry W. Gibbons +5 more
TL;DR: Higher levels of physical fitness appear to delay all-cause mortality primarily due to lowered rates of cardiovascular disease and cancer, and lower mortality rates in higher fitness categories also were seen for cardiovascular Disease and cancer of combined sites.
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Oxidative Stress, Caloric Restriction, and Aging
TL;DR: Support for this hypothesis includes the following observations: (i) Overexpression of antioxidative enzymes retards the age-related accrual of oxidative damage and extends the maximum life-span of transgenic Drosophila melanogaster and (ii) Variations in longevity among different species inversely correlate with the rates of mitochondrial generation of the superoxide anion radical and hydrogen peroxide.
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Role of leptin in the neuroendocrine response to fasting
Rexford S. Ahima,Daniel Prabakaran,Christos S. Mantzoros,Daqing Qu,Bradford B. Lowell,Eleftheria Maratos-Flier,Jeffrey S. Flier +6 more
TL;DR: It is proposed that regulation of the neuroendocrine system during starvation could be the main physiological role of leptin, and preventing the starvation-induced fall in leptin with exogenous leptin substantially blunts the changes in gonadal, adrenal and thyroid axes in male mice, and prevents the starve-induced delay in ovulation in female mice.