Leopoldo Santos-Argumedo

TL;DR: Soluble CD38 catalyzed the formation and hydrolysis of cadPR when added to NAD+.

TL;DR: It is shown that CD40 engagement arrests B cell differentiation prior to plasma cell formation, and this arrest is manifested at a molecular level as a reduction in mRNA levels of secretory immunoglobulin gene products and the loss of the transcriptional regulator BLIMP-1.

TL;DR: NIM-R5 induces an Ig-independent activation and proliferation of resting and activated B cells and is proposed that the p42 Ag is a glycoprotein with an important role in the regulation of B lymphocyte activation and survival.

TL;DR: It is interesting that T cells expressing high levels of CD38 had a reduced, proliferative capacity but displayed an improved potential to produce interleukin‐2 and interferon‐γ, suggesting a role of this molecule during T cell activation and differentiation.

TL;DR: Northern blot analysis of the expression of this cDNA product in a variety of cell types, together with immunoprecipitation of the recombinant protein expressed in BaF3 cells, indicated that I-19 cDNA encodes not only the epitope recognized by NIM-R5 but also a protein that is indistinguishable biochemically and in terms of distribution from the murine B cell activation marker recognized by MAb.