L
Les Huson
Researcher at Imperial College London
Publications - 25
Citations - 2482
Les Huson is an academic researcher from Imperial College London. The author has contributed to research in topics: Placebo-controlled study & Intention-to-treat analysis. The author has an hindex of 12, co-authored 25 publications receiving 2246 citations. Previous affiliations of Les Huson include University of Giessen & United Kingdom Ministry of Agriculture, Fisheries and Food.
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Journal ArticleDOI
Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia.
Adriano Lazzarin,Bonaventura Clotet,David A. Cooper,Jacques Reynes,Keikawus Arastéh,Mark Nelson,Christine Katlama,Hans Jürgen Stellbrink,Jean François Delfraissy,Joep M. A. Lange,Les Huson,Ralph DeMasi,Cynthia Wat,John Delehanty,Claude Drobnes,Miklos Salgo +15 more
TL;DR: The T-20 vs. Optimized Regimen Only Study 2 (TORO 2) as discussed by the authors compared the efficacy and safety of 24 weeks of treatment with the fusion inhibitor enfuvirtide in combination with an optimized background antiretroviral regimen with the efficacy of the optimized background regimen alone.
Journal ArticleDOI
Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza.
Frederick G. Hayden,Robert L. Atmar,Margo Schilling,Casey T. Johnson,Donald Poretz,David Paar,Les Huson,Penelope Ward,Roger G. Mills +8 more
TL;DR: Oseltamivir administered daily for six weeks by the oral route is safe and effective for the prevention of influenza.
Journal ArticleDOI
Effectiveness of Oseltamivir in Preventing Influenza in Household Contacts: A Randomized Controlled Trial
Robert Welliver,Arnold S. Monto,Otmar Carewicz,Edwig Schatteman,Michael Hassman,James Hedrick,Helen C. Jackson,Les Huson,Penelope Ward,John S. Oxford +9 more
TL;DR: This article investigated the efficacy of oseltamivir in preventing spread of influenza to household contacts of influenza-infected index cases (ICs) within 48 hours of symptom onset in the IC.
Journal ArticleDOI
Quality of Life and Physical Function in Older Patients on Dialysis: A Comparison of Assisted Peritoneal Dialysis with Hemodialysis
Osasuyi Iyasere,Edwina A. Brown,Lina Johansson,Les Huson,Joanna Smee,Alexander P. Maxwell,Ken Farrington,Andrew Davenport +7 more
TL;DR: There are no differences in measures of QoL and physical function between older patients on assisted PD and comparable patients on HD, except for treatment satisfaction, which is higher in patients on PD.
Journal ArticleDOI
Reduced MicroRNA-150 Is Associated with Poor Survival in Pulmonary Arterial Hypertension
Christopher J. Rhodes,John Wharton,John Wharton,Reinier A. Boon,Tino Roexe,Hilda Tsang,Beata Wojciak-Stothard,Anob Chakrabarti,Anob Chakrabarti,Luke Howard,J. Simon R. Gibbs,Allan Lawrie,Allan Lawrie,Robin Condliffe,Charles A. Elliot,David G. Kiely,David G. Kiely,Les Huson,Hossein Ardeschir Ghofrani,Henning Tiede,Ralph T. Schermuly,Andreas M. Zeiher,Stefanie Dimmeler,Martin R. Wilkins,Martin R. Wilkins +24 more
TL;DR: Reduction in circulating miR-150 levels were significantly reduced in circulating microvesicles from patients with PAH and the lungs of the monocrotaline rat, indicating poor survival in PAH.