L
Lesley J. Bruce
Researcher at University of Bristol
Publications - 39
Citations - 2448
Lesley J. Bruce is an academic researcher from University of Bristol. The author has contributed to research in topics: Band 3 & Distal renal tubular acidosis. The author has an hindex of 25, co-authored 36 publications receiving 2294 citations. Previous affiliations of Lesley J. Bruce include University College London & National Blood Service.
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Journal ArticleDOI
A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane
Lesley J. Bruce,Roland Beckmann,M. Letícia Ribeiro,Luanne L. Peters,Joel Anne Chasis,Jean Delaunay,Narla Mohandas,D J Anstee,Michael J. A. Tanner +8 more
TL;DR: Results suggest that band 3 forms the core of a macrocomplex of integral and peripheral RBC membrane proteins that may function as an integrated CO(2)/O(2) gas exchange unit (metabolon) in the erythrocyte.
Journal ArticleDOI
Familial distal renal tubular acidosis is associated with mutations in the red cell anion exchanger (Band 3, AE1) gene
Lesley J. Bruce,DL Cope,G. K. Jones,A. E. Schofield,M. Burley,Sue Povey,Robert J. Unwin,Oliver Wrong,Michael J. A. Tanner +8 more
TL;DR: In this paper, the authors found that all affected patients in four families with autosomal dominant familial renal tubular acidosis (dRTA) were heterozygous for mutations in their red cell HCO3/Cl- exchanger, band 3 (AE1, SLC4A1) genes, and these mutations were not found in any of the nine normal family members studied.
Journal ArticleDOI
Band 3 mutations, renal tubular acidosis and South-East Asian ovalocytosis in Malaysia and Papua New Guinea: loss of up to 95% band 3 transport in red cells.
Lesley J. Bruce,O Wrong,Ashley M. Toye,Mark T. Young,Graham D. Ogle,Zulkifli Ismail,Ashim K. Sinha,Paddy Mcmaster,Ilomo Hwaihwanje,Gerard B. Nash,Sarah R. Hart,Evelyn Lavu,Ronald Palmer,Ainoon Othman,Robert J. Unwin,Michael J. A. Tanner +15 more
TL;DR: Red-cell and Xenopus oocyte expression studies showed that the DeltaV850 and A858D mutant proteins have greatly decreased anion transport activity when present as compound heterozygotes, suggesting dRTA might arise by a different mechanism for each mutation.
Journal ArticleDOI
Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1
Lesley J. Bruce,Robinson Hc,Hélène Guizouarn,Franck Borgese,Penny J. Harrison,King Mj,Goede Js,Coles Se,Daniel M. Gore,Lutz Hu,Ficarella R,Layton Dm,Achille Iolascon,J.C Ellory,Gordon W. Stewart +14 more
TL;DR: In this paper, the authors identified 11 human pedigrees with dominantly inherited hemolytic anemias in both the hereditary stomatocytosis and spherocytosis classes.
Journal ArticleDOI
Changes in the blood group Wright antigens are associated with a mutation at amino acid 658 in human erythrocyte band 3: a site of interaction between band 3 and glycophorin A under certain conditions.
Lesley J. Bruce,Susan M. Ring,David J. Anstee,Marion E. Reid,Susan Wilkinson,Michael J. A. Tanner +5 more
TL;DR: Examination of the amino acid sequence and Wrb antigen expression of GPA-related hybrid glycophorins suggests that Arg61 of GPA interacts with Glu658 of band 3 to form the Wr(a+b-) antigen.