Sarah R. Hart

TL;DR: It is shown that RNAi-mediated ablation of various proteins identified in the trypanosome flagellar proteome leads to a rapid and marked failure of cytokinesis in bloodstream-form (but not procyclic insect-form)trypanosomes, suggesting that impairment of flageLLar function may provide a method of disease control.

TL;DR: This work constitutes a first comprehensive systems biology study on growth-rate control in the eukaryotic cell and has direct implications for advanced studies on cell growth, in vivo regulation of metabolic fluxes for comprehensive metabolic engineering, and for the design of genome-scale systems biology models of the eUKaryoticcell.

TL;DR: Red-cell and Xenopus oocyte expression studies showed that the DeltaV850 and A858D mutant proteins have greatly decreased anion transport activity when present as compound heterozygotes, suggesting dRTA might arise by a different mechanism for each mutation.

TL;DR: The PEDRo database provides access to a collection of comprehensive descriptions of experimental data sets in proteomics and serves to extend the debate on the level of detail at which proteomics data should be captured, the sorts of facilities that should be provided by proteome data management systems, and the techniques by which such facilities can be made available.

TL;DR: The combined protocol enabled the detection and sequencing of phosphopeptides from protein digests at low femtomole concentrations of initial sample and was employed to identify novel phosphorylation sites on the cell adhesion protein p120 catenin and the glycoprotein fetuin.