L
Lesley M McGregor
Researcher at University of Stirling
Publications - 64
Citations - 2191
Lesley M McGregor is an academic researcher from University of Stirling. The author has contributed to research in topics: Cancer screening & Population. The author has an hindex of 22, co-authored 62 publications receiving 1823 citations. Previous affiliations of Lesley M McGregor include Boston Children's Hospital & Edinburgh Royal Infirmary.
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Journal ArticleDOI
Mutations in the gene encoding filamin A as a cause for familial cardiac valvular dystrophy.
Florence Kyndt,Jean-Pierre Gueffet,Vincent Probst,Philippe Jaafar,Antoine Legendre,Françoise Le Bouffant,Claire Toquet,Estelle Roy,Lesley M McGregor,Sally Ann Lynch,Ruth Newbury-Ecob,Vinh Tran,Ian S. Young,Jean-Noël Trochu,Hervé Le Marec,Jean-Jacques Schott +15 more
TL;DR: The data demonstrate that FLNA is the first gene known to cause isolated nonsyndromic MVD, the first step to understanding the pathophysiological mechanisms of the disease and to defining pathways that may lead to valvular dystrophy.
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Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein
Lesley M McGregor,Vile Makela,Susan M. Darling,Susan M. Darling,Sofia Vrontou,Georges Chalepakis,Catherine Roberts,Nicola Smart,Paul Rutland,Natalie J. Prescott,Jason Hopkins,Elizabeth Bentley,Alison Shaw,Emma Roberts,Robert F. Mueller,Shalini Jadeja,Nicole Philip,John Nelson,Christine Francannet,Antonio Perez-Aytes,André Mégarbané,Bronwyn Kerr,Brandon J. Wainwright,Adrian S. Woolf,Robin M. Winter,Peter J. Scambler +25 more
TL;DR: It is shown that the locus FS1 at chromosome 4q21 is associated with Fraser syndrome, although the condition is genetically heterogeneous, and the mouse is a model for Fraser syndrome in humans, a disorder caused by disrupted epithelial integrity in utero.
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A Mechanism for Gene-Environment Interaction in the Etiology of Congenital Scoliosis
Duncan B. Sparrow,Duncan B. Sparrow,Gavin Chapman,Gavin Chapman,Allanceson J. Smith,Muhammad Z. Mattar,J.A. Major,Victoria C. O'Reilly,Yumiko Saga,Elaine H. Zackai,Elaine H. Zackai,John P. Dormans,John P. Dormans,Benjamin A. Alman,Lesley M McGregor,Ryoichiro Kageyama,Kenro Kusumi,Sally L. Dunwoodie,Sally L. Dunwoodie +18 more
TL;DR: It is demonstrated that haploinsufficiency of Notch signaling pathway genes in humans can cause congenital scoliosis, and that in a mouse model, the combination of this genetic risk factor with an environmental condition significantly increases the penetrance and severity of vertebral defects.
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Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs.
Shalini Jadeja,Ian M. Smyth,Ian M. Smyth,Jolanta E. Pitera,Martin S. Taylor,Mieke M. van Haelst,Elizabeth Bentley,Lesley M McGregor,Jason Hopkins,Georges Chalepakis,Nicole Philip,Antonio Perez Aytes,Fiona M. Watt,Susan M. Darling,Ian J. Jackson,Adrian S. Woolf,Peter J. Scambler +16 more
TL;DR: This work mapped my to Frem2, a gene related to Fras1 and Frem1, and showed that a Frem2 gene-trap mutation was allelic to my, suggesting that calcium binding in the CALXβ-cadherin motif is important for normal functioning of FREM2.
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Understanding public trust in services provided by community pharmacists relative to those provided by general practitioners: a qualitative study.
TL;DR: The authors' data indicate that the nature and context of public interactions with GPs fostered familiarity with a specific GP or practice, which allowed interpersonal trust to develop, and that the public will trust pharmacists to deliver unfamiliar services, particularly those perceived to be ‘high risk’.