G
Georges Chalepakis
Researcher at University of Crete
Publications - 48
Citations - 4629
Georges Chalepakis is an academic researcher from University of Crete. The author has contributed to research in topics: FRAS1 & Hormone response element. The author has an hindex of 30, co-authored 47 publications receiving 4488 citations. Previous affiliations of Georges Chalepakis include University of Marburg & Max Planck Society.
Papers
More filters
Journal ArticleDOI
Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.
TL;DR: The isolation and characterization of Pax‐3 is described, a novel murine paired box gene expressed exclusively during embryogenesis that specifically recognizes the e5 sequence present upstream of the Drosophila even‐skipped gene.
Journal ArticleDOI
Gene regulation by steroid hormones.
TL;DR: The location, orientation, and structure of the hormone regulatory elements (HRE) in nine hormonally modulated genes is described and a model for the interaction is proposed in which a dimer of the receptor in head-to-head orientation binds to the inverted symmetry element of the HRE.
Journal ArticleDOI
DNA regulatory elements for steroid hormones
TL;DR: The possible role of precise chromatin organization in glucocorticoid induction is discussed on the basis of the nucleosome phasing found in the LTR region of mouse mammary tumour virus.
Journal ArticleDOI
The molecular basis of the undulated/Pax-1 mutation.
Georges Chalepakis,Rüdiger Fritsch,Helmut Fickenscher,Urban Deutsch,Martyn Goulding,Peter Gruss +5 more
TL;DR: It is shown that Pax-1 encodes a DNA-binding protein with transcriptional activating properties that is closely associated with the mouse developmental mutant undulated (un), which exhibits malformations in the vertebral column.
Journal ArticleDOI
Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein
Lesley M McGregor,Vile Makela,Susan M. Darling,Susan M. Darling,Sofia Vrontou,Georges Chalepakis,Catherine Roberts,Nicola Smart,Paul Rutland,Natalie J. Prescott,Jason Hopkins,Elizabeth Bentley,Alison Shaw,Emma Roberts,Robert F. Mueller,Shalini Jadeja,Nicole Philip,John Nelson,Christine Francannet,Antonio Perez-Aytes,André Mégarbané,Bronwyn Kerr,Brandon J. Wainwright,Adrian S. Woolf,Robin M. Winter,Peter J. Scambler +25 more
TL;DR: It is shown that the locus FS1 at chromosome 4q21 is associated with Fraser syndrome, although the condition is genetically heterogeneous, and the mouse is a model for Fraser syndrome in humans, a disorder caused by disrupted epithelial integrity in utero.