L
Li Ji
Researcher at Zhejiang University
Publications - 28
Citations - 514
Li Ji is an academic researcher from Zhejiang University. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 13, co-authored 24 publications receiving 388 citations. Previous affiliations of Li Ji include Kyoto University & China University of Mining and Technology.
Papers
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Journal ArticleDOI
Drug metabolism by cytochrome p450 enzymes: what distinguishes the pathways leading to substrate hydroxylation over desaturation?
Li Ji,Abayomi S. Faponle,Matthew G. Quesne,Mala A. Sainna,Jing Zhang,Alicja Franke,Devesh Kumar,Rudi van Eldik,Rudi van Eldik,Weiping Liu,Sam P. de Visser +10 more
TL;DR: These studies imply that bioengineering P450 isozymes for desaturation reactions will have to include modifications in the substrate binding pocket to restrict the hydroxylation rebound reaction.
Journal ArticleDOI
Metabolic Mechanism of Aryl Phosphorus Flame Retardants by Cytochromes P450: A Combined Experimental and Computational Study on Triphenyl Phosphate
Quan Zhang,Shujing Ji,Lihong Chai,Fangxing Yang,Meirong Zhao,Weiping Liu,Gerrit Schüürmann,Li Ji +7 more
TL;DR: In vitro study shows that TPHP is metabolized into its diester metabolite DPHP and mono- and dihydroxylated metabolites by cytochromes P450 (CYP) in human liver microsomes, while CYP1A2 and CYP2E1 isoforms are mainly involved in such processes.
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Molecular Mechanism of Alternative P450-Catalyzed Metabolism of Environmental Phenolic Endocrine-Disrupting Chemicals.
TL;DR: D density functional theory is used to investigate the P450-catalyzed ipso-substitution mechanism of the prominent xenoestrogen bisphenol A and identifies pathways applicable for prediction of metabolites from phenolic EDCs whose fate are affected by this alternative type of P450 reactivity.
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Combined Experimental and Theoretical Study on the Reactivity of Compounds I and II in Horseradish Peroxidase Biomimetics
Li Ji,Li Ji,Alicja Franke,Małgorzata Brindell,Maria Oszajca,Achim Zahl,Rudi van Eldik,Rudi van Eldik +7 more
TL;DR: The combined experimental and theoretical study on the elucidation of the intrinsic reactivity patterns of theHRP-I and HRP-II mimics provides a valuable tool for evaluating the particular role of the HRP active species in biological systems.
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Mechanism of Cobalamin-Mediated Reductive Dehalogenation of Chloroethylenes
TL;DR: In this article, the authors used experimentally calibrated density functional theory on a realistic cobalamin model to resolve controversies of cobalmin-mediated reduction of chloroethylenes.