Mala A. Sainna

TL;DR: It is clear that the support functionality can play a crucial role in tuning the catalytic activity that is observed and that advanced theory and characterization add greatly to the understanding of these fascinating catalysts.

TL;DR: These studies imply that bioengineering P450 isozymes for desaturation reactions will have to include modifications in the substrate binding pocket to restrict the hydroxylation rebound reaction.

TL;DR: In this article, a model complex of cyclotron resonance (FT-ICR) mass spectrometry (MS) was used to study the reaction of [FeIII(TPFPP)]+ with iodosylbenzene as a terminal oxidant, which leads to the production of ions corresponding to [FeIV(O)(TPP+˙)]+ for the first time.

TL;DR: The calculations give important new insights into distal hydrogen bonding, and show that in biomimetic, and, by extension, enzymatic systems, the hydrogen bond may be important for proton-relay mechanisms involved in the formation of the metal-oxo intermediates, but the enzyme pays the price for this by reduced hydrogen atom abstraction ability of the intermediate.

TL;DR: A systematic gas-phase study on reactions by iron(IV)-oxo porphyrin cation radical structures with arenes confirms the experimental hypothesis of dominant aromatic over aliphatic hydroxylation and shows that the lack of an axial ligand affects theAliphatic pathways.