Li Li

TL;DR: Peptide-based vaccines against SARS-CoV could be engineered to avoid ADE via elimination of the S597–603 epitope, an alternative strategy to prepare a safe and effective vaccine for ADE of viral infection by identifying and eliminating epitope sequence-dependent enhancement of viral infections.

TL;DR: The study demonstrated that S(471-503) peptide was a potential immunoantigen for the development of peptide-based vaccine or a candidate for further drug evaluation against the SARS-CoV virus-cell fusion.

TL;DR: The synthesis of benzo[1,4]oxazin-3-one-based compounds from 1,5-difluoro-2,4-dinitrobenzene was discussed, and a chemical library based on 15 was synthesized in parallel solution-phase reactions.

TL;DR: An efficient solution-phase parallel synthesis of multisubstituted 5-aminobenzimidazoles is described, which results in 2,4,5-benzenetriamines, which are continuously condensed with aldehydes to successfully construct the benzimidzole ring without additional oxidants.

TL;DR: Preliminary pharmacological activity of 2-quinoxalinol analogues is obtained for the inhibition of LPS-induced TNF-alpha release on mouse macrophage in vitro.