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Yanfeng Xu
Researcher at Peking Union Medical College
Publications - 88
Citations - 7883
Yanfeng Xu is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Virus & Viral load. The author has an hindex of 30, co-authored 85 publications receiving 5821 citations. Previous affiliations of Yanfeng Xu include Chinese Ministry of Health.
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Journal ArticleDOI
Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells.
Y Cao,Bin Su,Xianghua Guo,Wenjie Sun,Yong-Qiang Deng,Linlin Bao,Qinyu Zhu,Xu Zhang,Yinghui Zheng,Chenyang Geng,Xiaoran Chai,Runsheng He,Xiaofeng Li,Qi Lv,Hua Zhu,Wei Deng,Yanfeng Xu,Yanjun Wang,Luxin Qiao,Yafang Tan,Liyang Song,Guopeng Wang,Xiao-Xia Du,Ning Gao,Jiangning Liu,Junyu Xiao,Xiao-Dong Su,Zongmin Du,Yingmei Feng,Chuan Qin,Cheng-Feng Qin,Ronghua Jin,X. Sunney Xie +32 more
TL;DR: It is shown that human neutralizing antibodies could be efficiently discovered by high-throughput single B-cell sequencing in response to pandemic infectious diseases.
Journal ArticleDOI
From SARS to MERS, Thrusting Coronaviruses into the Spotlight
Zhiqi Song,Yanfeng Xu,Linlin Bao,Ling Zhang,Pin Yu,Yajin Qu,Hua Zhu,Wenjie Zhao,Yunlin Han,Chuan Qin +9 more
TL;DR: The research still needed to fully elucidate the pathogenic mechanism of these viruses, to construct reproducible animal models, and ultimately develop countermeasures to conquer not only SARS-CoV and MERS-coV, but also these emerging coronaviral diseases are outlined.
Journal ArticleDOI
The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice.
Linlin Bao,Wei Deng,Baoying Huang,Hong Gao,Jiangning Liu,Lili Ren,Qiang Wei,Pin Yu,Yanfeng Xu,Feifei Qi,Yajin Qu,Fengdi Li,Qi Lv,Wenling Wang,Jing Xue,Shuran Gong,Mingya Liu,Guanpeng Wang,Shunyi Wang,Zhiqi Song,Linna Zhao,Peipei Liu,Li Zhao,Fei Ye,Huijuan Wang,Weimin Zhou,Na Zhu,Wei Zhen,Haisheng Yu,Xiaojuan Zhang,Li Guo,Lan Chen,Conghui Wang,Ying Wang,Xinming Wang,Yan Xiao,Qiangming Sun,Hongqi Liu,Fanli Zhu,Chunxia Ma,Lingmei Yan,Mengli Yang,Jun Han,Wenbo Xu,Wenjie Tan,Xiaozhong Peng,Qi Jin,Guizhen Wu,Chuan Qin +48 more
TL;DR: This mouse model of SARS-CoV-2 infection will be valuable for evaluating antiviral therapeutic agents and vaccines, as well as understanding the pathogenesis of COVID-19.
Journal ArticleDOI
Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2.
Hui Wang,Yuntao Zhang,Baoying Huang,Wei Deng,Yaru Quan,Wenling Wang,Wenbo Xu,Yuxiu Zhao,Na Li,Jin Zhang,Hongyang Liang,Linlin Bao,Yanfeng Xu,Ling Ding,Weimin Zhou,Hong Gao,Jiangning Liu,Peihua Niu,Li Zhao,Wei Zhen,Hui Fu,Yu Shouzhi,Zhang Zhengli,Guangxue Xu,Changgui Li,Zhiyong Lou,Miao Xu,Chuan Qin,Guizhen Wu,George F. Gao,Wenjie Tan,Xiaoming Yang +31 more
TL;DR: Two-dose immunizations using 2 μg/dose of BBIBP-CorV provided highly efficient protection against SARS-CoV-2 intratracheal challenge in rhesus macaques, without detectable antibody-dependent enhancement of infection.
Journal ArticleDOI
Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques.
Wei Deng,Linlin Bao,Jiangning Liu,Chong Xiao,Jiayi Liu,Jing Xue,Qi Lv,Feifei Qi,Hong Gao,Pin Yu,Yanfeng Xu,Yajin Qu,Fengdi Li,Zhiguang Xiang,Haisheng Yu,Shuran Gong,Mingya Liu,Guanpeng Wang,Shunyi Wang,Zhiqi Song,Ying Liu,Wenjie Zhao,Yunlin Han,Linna Zhao,Xing Liu,Qiang Wei,Chuan Qin +26 more
TL;DR: Results suggest that primary SARS-CoV-2 exposure protects against subsequent reinfection in rhesus macaques, and this has key implications for public health and economic initiatives if validated in human studies.