Zijie Liu

TL;DR: Peptide-based vaccines against SARS-CoV could be engineered to avoid ADE via elimination of the S597–603 epitope, an alternative strategy to prepare a safe and effective vaccine for ADE of viral infection by identifying and eliminating epitope sequence-dependent enhancement of viral infections.

TL;DR: In this paper, a new compound, 10-chloromethyl-11-demethyl-12-oxo-calanolide A (20, EC50 = 7.4 nM, SI = 1417), was reported.

TL;DR: A Cp*CoIII-catalyzed arene C-H bond amidation/annulation of benzamides was developed to afford quinazolinone derivatives in one-pot with high yields and broad substrate scope.

TL;DR: A series of 2-[(2-pyridylmethyl)sulfinyl]benzimidazole derivatives were synthesized via a solution phase synthetic route using a reversal method of diversity introduction to identify potent H(+)/K(+)-ATP enzyme inhibitors in vitro.

TL;DR: A 1,4-benzodiazepine-2,5-dione (BZD) derivative is described for the first time that acts as a dual NOD1/NOD2 antagonist and inhibits both nuclear factor κB and mitogen-activated protein kinase (MAPK) inflammatory signaling, thereby sensitizing PTX to suppress Lewis lung carcinoma (LLC) growth.