L
Lianfeng Zhang
Researcher at Peking Union Medical College
Publications - 109
Citations - 3308
Lianfeng Zhang is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 30, co-authored 90 publications receiving 2677 citations. Previous affiliations of Lianfeng Zhang include Chinese Ministry of Health.
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Journal ArticleDOI
Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates
Qidi Wang,Lianfeng Zhang,Kazuhiko Kuwahara,Li Li,Zijie Liu,Taisheng Li,Hua Zhu,Jiangning Liu,Yanfeng Xu,Jing Xie,Hiroshi Morioka,Nobuo Sakaguchi,Chuan Qin,Gang Liu +13 more
TL;DR: Peptide-based vaccines against SARS-CoV could be engineered to avoid ADE via elimination of the S597–603 epitope, an alternative strategy to prepare a safe and effective vaccine for ADE of viral infection by identifying and eliminating epitope sequence-dependent enhancement of viral infections.
Journal ArticleDOI
miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation.
Xiaoying Wang,Peng Liu,Hua Zhu,Yanfeng Xu,Chunmei Ma,Xiaowei Dai,Lan Huang,Yali Liu,Lianfeng Zhang,Chuan Qin +9 more
TL;DR: It is shown that the expression of miR-34a is inversely correlated with the protein level of bcl2 in APPswe/PSDeltaE9 mice and age-matched controls, and miR -34a expression directly inhibits bCl2 translation in SH-SY5Y cells.
Journal ArticleDOI
Generating rats with conditional alleles using CRISPR/Cas9.
Yuanwu Ma,Xu Zhang,Bin Shen,Yingdong Lu,Wei Chen,Jing Ma,Lin Bai,Xingxu Huang,Lianfeng Zhang +8 more
TL;DR: The application of the CRISPR/Cas9 system is extended and an effective strategy to generate rats with conditional alleles is reported.
Journal ArticleDOI
Genome modification by CRISPR/Cas9.
TL;DR: The CRISPR–Cas9 system has been employed to recruit functional domains that repress/activate gene expression or label specific genomic loci in living cells or organisms, in order to explore developmental mechanisms, gene expression regulation, and animal behavior.
Journal ArticleDOI
MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis
Ming Su,Jianwei Wang,Chengfeng Wang,Xishan Wang,W Dong,W Qiu,Yongyan Wang,X Zhao,Yubao Zou,Li Song,Lianfeng Zhang,Rutai Hui +11 more
TL;DR: The findings reveal that miR-221 is an important regulator of autophagy balance and cardiac remodeling by modulating the p27/CDK2/mTOR axis, and implicate mi R-221 as a therapeutic target in heart failure.