L
Li Zhang
Researcher at University of Toronto
Publications - 34
Citations - 1757
Li Zhang is an academic researcher from University of Toronto. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 17, co-authored 31 publications receiving 1166 citations. Previous affiliations of Li Zhang include University Health Network & Kettering University.
Papers
More filters
Journal ArticleDOI
Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth
Sung Eun Kim,Li Zhang,Kai Ma,Michelle Riegman,Feng Chen,Irina Ingold,Marcus Conrad,Melik Z. Turker,Minghui Gao,Xuejun Jiang,Xuejun Jiang,Sebastien Monette,Mohan Pauliah,Mithat Gonen,Pat Zanzonico,Thomas P. Quinn,Ulrich Wiesner,Michelle S. Bradbury,Michael Overholtzer,Michael Overholtzer +19 more
TL;DR: It is shown that ultrasmall (< 10 nm in diameter) poly(ethylene glycol) (PEG)-coated silica nanoparticles, functionalized with melanoma-targeting peptides, can induce a form of programmed cell death known as ferroptosis in starved cancer cells and cancer-bearing mice.
Journal ArticleDOI
Tumor-infiltrating B cells: their role and application in anti-tumor immunity in lung cancer.
TL;DR: Recent clinical and preclinical studies that outline the role of TIBs in lung cancer development, assess their prognostic significance, and explore the potential benefit of B cell-based immunotherapy for lung cancer treatment are reviewed.
Journal ArticleDOI
Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer
Feng Chen,Kai Ma,Brian Madajewski,Li Zhuang,Li Zhang,Keith W Rickert,Marcello Marelli,Barney Yoo,Melik Z. Turker,Michael Overholtzer,Michael Overholtzer,Thomas P. Quinn,Mithat Gonen,Pat Zanzonico,Anthony Tuesca,Michael A. Bowen,Larry Norton,J. Anand Subramony,Ulrich Wiesner,Michelle S. Bradbury +19 more
TL;DR: In this paper, ultrasmall silica nanoparticles are functionalized with anti-human epidermal growth factor receptor 2 (HER2) single-chain variable fragments to exhibit high tumor-targeting efficiency and efficient renal clearance.
Journal ArticleDOI
Double-negative regulatory T cells: non-conventional regulators.
TL;DR: The characteristics, developmental pathways, and mechanisms of action of DN Treg cells, as well as their role in transplant tolerance, autoimmunity, and anticancer immunity, are summarized.
Journal ArticleDOI
Cutting Edge: In Vivo Trogocytosis as a Mechanism of Double Negative Regulatory T Cell-Mediated Antigen-Specific Suppression
TL;DR: It is demonstrated that murine DN Tregs acquire alloantigen in vivo via trogocytosis and express it on their cell surface and may enhance the ability to use DN T Regs as a therapy for transplant rejection and autoimmune diseases.