K
Kai Ma
Researcher at Cornell University
Publications - 50
Citations - 1836
Kai Ma is an academic researcher from Cornell University. The author has contributed to research in topics: Nanoparticle & Mesoporous silica. The author has an hindex of 17, co-authored 50 publications receiving 1370 citations. Previous affiliations of Kai Ma include Memorial Sloan Kettering Cancer Center & University of Science and Technology of China.
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Journal ArticleDOI
Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth
Sung Eun Kim,Li Zhang,Kai Ma,Michelle Riegman,Feng Chen,Irina Ingold,Marcus Conrad,Melik Z. Turker,Minghui Gao,Xuejun Jiang,Xuejun Jiang,Sebastien Monette,Mohan Pauliah,Mithat Gonen,Pat Zanzonico,Thomas P. Quinn,Ulrich Wiesner,Michelle S. Bradbury,Michael Overholtzer,Michael Overholtzer +19 more
TL;DR: It is shown that ultrasmall (< 10 nm in diameter) poly(ethylene glycol) (PEG)-coated silica nanoparticles, functionalized with melanoma-targeting peptides, can induce a form of programmed cell death known as ferroptosis in starved cancer cells and cancer-bearing mice.
Journal ArticleDOI
Ultrasmall Sub-10 nm Near-Infrared Fluorescent Mesoporous Silica Nanoparticles
TL;DR: This work describes the one-pot synthesis of PEGylated mesoporous silica nanoparticles with a single pore, tunable sizes around 9 nm and narrow size distributions that can be labeled with near-infrared dye Cy5.5.
Journal ArticleDOI
Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer
Feng Chen,Kai Ma,Brian Madajewski,Li Zhuang,Li Zhang,Keith W Rickert,Marcello Marelli,Barney Yoo,Melik Z. Turker,Michael Overholtzer,Michael Overholtzer,Thomas P. Quinn,Mithat Gonen,Pat Zanzonico,Anthony Tuesca,Michael A. Bowen,Larry Norton,J. Anand Subramony,Ulrich Wiesner,Michelle S. Bradbury +19 more
TL;DR: In this paper, ultrasmall silica nanoparticles are functionalized with anti-human epidermal growth factor receptor 2 (HER2) single-chain variable fragments to exhibit high tumor-targeting efficiency and efficient renal clearance.
Journal ArticleDOI
Control of Ultrasmall Sub-10 nm Ligand-Functionalized Fluorescent Core–Shell Silica Nanoparticle Growth in Water
Kai Ma,Carlie Mendoza,Margaret A. Hanson,Ulrike Werner-Zwanziger,Josef W. Zwanziger,Ulrich Wiesner +5 more
TL;DR: This methodology further enables synthesis of <10 nm sized fluorescent core and core–shell SNPs with previously unknown compositions, in particular, the addition of an aluminum sol gel precursor leads to fluorescent aluminosilicate nanoparticles (ASNPs) and core-shell ASNPs.
Journal Article
Ultrasmall Targeted Nanoparticles with Engineered Antibody Fragments for Imaging Detection of HER2-overexpressing Breast Cancer
Feng Chen,Kai Ma,Brian Madajewski,Marcello Marelli,Melik Z. Turker,Pat Zanzonico,Anand Subramony,Ulrich Wiesner,Michelle S. Bradbury +8 more
TL;DR: The conjugation of anti-HER2 scFv fragments to the silica nanoparticles is proposed, increasing specificity and limiting the final size of the immunoconjugates below the renal clearance threshold.