L
Lian Yang
Researcher at Huazhong University of Science and Technology
Publications - 2
Citations - 219
Lian Yang is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Viral replication & Viral load. The author has an hindex of 2, co-authored 2 publications receiving 158 citations.
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Journal ArticleDOI
Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques.
Chao Shan,Yanfeng Yao,Xing-Lou Yang,Yiwu Zhou,Ge Gao,Yun Peng,Lian Yang,Xue Hu,Jin Xiong,Ren-Di Jiang,Huajun Zhang,Xiaoxiao Gao,Cheng Peng,Juan Min,Ying Chen,Hao-Rui Si,Jia Wu,Peng Zhou,Yan-Yi Wang,Hongping Wei,Wei Pang,Zheng-Fei Hu,Longbao Lv,Yong-Tang Zheng,Zhengli Shi,Zhiming Yuan +25 more
TL;DR: It is demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2, and the non-human primate model that is established here provides a valuable platform to study Sars-Co V-2 pathogenesis and to evaluate candidate vaccines and therapeutics.
Journal ArticleDOI
Protective Efficacy of Inactivated Vaccine against SARS-CoV-2 Infection in Mice and Non-Human Primates.
Yan Feng Yao,Ze Jun Wang,Ren Di Jiang,Xue Hu,Hua Jun Zhang,Yi Wu Zhou,Ge Gao,Ying Chen,Yun Peng,Mei Qin Liu,Ya-Nan Zhang,Juan Min,Jia Lu,Xiao Xiao Gao,Jing Guo,Cheng Peng,Xu Rui Shen,Li Qian,Kai Zhao,Lian Yang,Xin Wan,Bo Zhang,Wenhui Wang,Jia Wu,Peng Zhou,Xing-Lou Yang,Shuo Shen,Chao Shan,Zhiming Yuan,Zhengli Shi +29 more
TL;DR: In this paper, the safety, immunogenicity, and efficacy of an inactivated vaccine based on the whole viral particles in human ACE2 transgenic mouse and in non-human primates were evaluated.