Z
Zhiming Yuan
Researcher at Chinese Academy of Sciences
Publications - 187
Citations - 6465
Zhiming Yuan is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Virus & Bacillus thuringiensis. The author has an hindex of 35, co-authored 166 publications receiving 4671 citations.
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Journal ArticleDOI
A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2.
Rui Shi,Chao Shan,Xiaomin Duan,Zhihai Chen,Peipei Liu,Jin-Wen Song,Tao Song,Tao Song,Xiaoshan Bi,Xiaoshan Bi,Chao Han,Lianao Wu,Lianao Wu,Ge Gao,Xue Hu,Ya-Nan Zhang,Zhou Tong,Weijin Huang,William J. Liu,Guizhen Wu,Bo Zhang,Lan Wang,Jianxun Qi,Hui Feng,Fu-Sheng Wang,Qihui Wang,George F. Gao,Zhiming Yuan,Jinghua Yan +28 more
TL;DR: Two monoclonal antibodies isolated from a patient with COVID-19 are shown to interfere with SARS-CoV-2–receptor binding, and one displays potent action against this virus in vitro and in a rhesus macaque model.
Journal ArticleDOI
Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes: Interim Analysis of 2 Randomized Clinical Trials.
Shengli Xia,Kai Duan,Yuntao Zhang,Dongyang Zhao,Huajun Zhang,Zhiqiang Xie,Xinguo Li,Cheng Peng,Yan-Bo Zhang,Wei Zhang,Yunkai Yang,Wei Chen,Xiaoxiao Gao,Wangyang You,Xue-Wei Wang,Zejun Wang,Zhengli Shi,Y. Wang,Xuqin Yang,Lianghao Zhang,Lili Huang,Qian Wang,Jia Lu,Yongli Yang,Jing Guo,Wei Zhou,Xin Wan,Cong Wu,Wenhui Wang,Shihe Huang,Du Jianhui,Ziyan Meng,An Pan,Zhiming Yuan,Shuo Shen,Wanshen Guo,Xiaoming Yang +36 more
TL;DR: In this interim report of the phase 1 and phase 2 trials of an inactivated COVID-19 vaccine, patients had a low rate of adverse reactions and demonstrated immunogenicity; the study is ongoing.
Journal ArticleDOI
Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques.
Chao Shan,Yanfeng Yao,Xing-Lou Yang,Yiwu Zhou,Ge Gao,Yun Peng,Lian Yang,Xue Hu,Jin Xiong,Ren-Di Jiang,Huajun Zhang,Xiaoxiao Gao,Cheng Peng,Juan Min,Ying Chen,Hao-Rui Si,Jia Wu,Peng Zhou,Yan-Yi Wang,Hongping Wei,Wei Pang,Zheng-Fei Hu,Longbao Lv,Yong-Tang Zheng,Zhengli Shi,Zhiming Yuan +25 more
TL;DR: It is demonstrated that neutralizing antibodies generated from the primary infection could protect the Rhesus macaques from a second-round challenge by SARS-CoV-2, and the non-human primate model that is established here provides a valuable platform to study Sars-Co V-2 pathogenesis and to evaluate candidate vaccines and therapeutics.
Journal ArticleDOI
An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques.
Liqiang Feng,Liqiang Feng,Qian Wang,Qian Wang,Chao Shan,Chenchen Yang,Ying Feng,Jia Wu,Liu Xiaolin,Yiwu Zhou,Ren-Di Jiang,Peiyu Hu,Xinglong Liu,Fan Zhang,Pingchao Li,Xuefeng Niu,Yichu Liu,Xuehua Zheng,Jia Luo,Jing Sun,Yingying Gu,Bo Liu,Yongcun Xu,Chufang Li,Weiqi Pan,Jincun Zhao,Changwen Ke,Xinwen Chen,Tao Xu,Nanshan Zhong,Guan Suhua,Zhiming Yuan,Ling Chen,Ling Chen +33 more
TL;DR: A replication-incompetent adenovirus based vaccine expressing SARS-CoV-2 spike is generated, protection from infection in non-human primates is shown, and the immune response after intramuscular and intranasal vaccination is analyzed.
Posted ContentDOI
Diagnosis of Acute Respiratory Syndrome Coronavirus 2 Infection by Detection of Nucleocapsid Protein
Bo Diao,Wen Kun,Junjie Chen,Yang Liu,Zhiming Yuan,Chao Han,Yue Pan,Ling Chen,Dan Y,Wang J,Chen Y,Deng G,Hongwei Zhou,Yuzhang Wu +13 more
TL;DR: Findings indicate that nucleocapsid protein assay is an accurate, rapid, early and simple method for diagnosis of COVID-19, a suspected SARS-CoV-2 infection.