L
Liang Guo
Researcher at Jiangnan University
Publications - 51
Citations - 686
Liang Guo is an academic researcher from Jiangnan University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 8, co-authored 25 publications receiving 300 citations.
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Journal ArticleDOI
DCEO Biotechnology: Tools To Design, Construct, Evaluate, and Optimize the Metabolic Pathway for Biosynthesis of Chemicals
Xiulai Chen,Cong Gao,Liang Guo,Guipeng Hu,Qiuling Luo,Jia Liu,Jens Nielsen,Jian Chen,Liming Liu +8 more
TL;DR: Recent progress of DCEO biotechnology and examples of its application are summarized, and insights as to when, what and how different strategies should be taken are provided.
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Programmable biomolecular switches for rewiring flux in Escherichia coli.
Cong Gao,Jianshen Hou,Peng Xu,Liang Guo,Xiulai Chen,Guipeng Hu,Chao Ye,Harley Edwards,Jian Chen,Wei Chen,Liming Liu +10 more
TL;DR: Two sets of controllable protein units are built using engineered viral proteases and proteolytic signals for increasing titers of shikimate and D-xylonate in E. coli, highlighting the applicability of programmable protein switches to metabolic engineering for valuable chemicals production.
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Engineering Escherichia coli for malate production by integrating modular pathway characterization with CRISPRi-guided multiplexed metabolic tuning
TL;DR: It is demonstrated that in vitro modular pathway optimization combined with in vivo multiplexed combinatorial engineering enables effective characterization of the bottleneck of a complex biosynthetic cascade and improves the output of the engineered pathway.
Journal ArticleDOI
Light-powered Escherichia coli cell division for chemical production.
Qiang Ding,Danlei Ma,Gao-Qiang Liu,Yang Li,Liang Guo,Cong Gao,Guipeng Hu,Chao Ye,Jia Liu,Liming Liu,Xiulai Chen +10 more
TL;DR: An optogenetic method is employed to realize dynamic morphological engineering of E. coli replication and division and shows the increased production of acetoin and poly(lactate-co-3-hydroxybutyrate).
Journal ArticleDOI
Engineering Escherichia coli lifespan for enhancing chemical production
TL;DR: E engineering the lifespan of Escherichia coli is presented as a platform technology for improving the bioproduction of chemicals to improve the chemical production of poly(lactate-co-3-hydroxybutyrate) and butyrate.