Showing papers by "Liang Hong published in 2018"
TL;DR: FMK-9a may plays multiple roles in autophagy process and cannot simply take it as an ATG4B inhibitor, and it is demonstrated that ATG 4B inhibitor FMK- 9a induces autophagic independent on its enzyme inhibition.
39 citations
TL;DR: The asymmetric dearomatization/oxa-Michael reaction and Friedel–Crafts alkylation of 1-naphthols at the C4 position is reported, wherein the chemoselectivity could be switched easily by using different reaction conditions without changing the catalyst and the substrates.
Abstract: Switching the chemo- or regioselectivity from identical starting materials under readily tunable reaction conditions represents a great challenge in medicinal and synthetic organic chemistry. Herein, we report the asymmetric dearomatization/oxa-Michael reaction and Friedel–Crafts alkylation of 1-naphthols at the C4 position, wherein the chemoselectivity could be switched easily by using different reaction conditions without changing the catalyst and the substrates. The reactions feature asymmetric Friedel–Crafts alkylation of 1-naphthols at the C4 position and asymmetric dearomatization without using specific substrates or stepwise protocols.
38 citations
TL;DR: To the best of the knowledge, this represents the first [2+2] cyclization of azlactones with imines and the first asymmetric PPA rearrangement, which are linked together by the phosphoric acid catalyst.
Abstract: Enantioselective synthesis of imidazolidin-5-ones through a phosphoric acid catalyzed reaction between azlactones and N-substituted β-carbolines is reported. The reaction takes place via an initial formal [2+2] cycloaddition to generate an α-amino-β-lactam, which subsequently undergoes an acid-catalyzed asymmetric penicillin-penillonic acid (PPA) rearrangement with high diastereo- and enantioselectivity. To the best of our knowledge, this represents the first [2+2] cyclization of azlactones with imines and the first asymmetric PPA rearrangement, which are linked together by the phosphoric acid catalyst.
26 citations
TL;DR: The reaction is used for the first synthesis of chiral α,γ-diamino diacid derivatives with nonadjacent stereogenic centers in moderate to high yields, with excellent diastereo- and enantioselectivities, under the catalysis of a chiral thiourea catalyst.
25 citations
TL;DR: An economical, convenient and eco-friendly procedure for the one-pot synthesis of β-haloketones with an α-quaternary carbon center via the tandem halogenation/semipinacol rearrangement of allyl alcohols with NaX (X = Cl, Br, I) under open-air conditions has been demonstrated.
16 citations
TL;DR: This protocol provides an atomically economical, catalyst-free and simple route for the construction of synthetically useful 3-(3-indolyl)-oxindole-3-methanols in high yields with complete retention of enantioselectivity.
Abstract: A highly efficient strategy for the regio- and stereospecific Friedel-Crafts alkylation of indoles with spiro-epoxyoxindoles has been developed in the mixed solvents of HFIP/H2O (1 : 9) without the use of catalysts. This protocol provides an atomically economical, catalyst-free and simple route for the construction of synthetically useful 3-(3-indolyl)-oxindole-3-methanols in high yields. Starting from optically active spiro-epoxyoxindoles a variety of enantiospecific 3-(3-indolyl)-oxindole-3-methanols could be obtained in high yields with complete retention of enantioselectivity.
6 citations