Liang Ouyang

TL;DR: Understanding PCD and the complex interplay between apoptosis, autophagy and programmed necrosis pathways and apoptosis‐related microRNA regulation, in cancer may ultimately allow scientists and clinicians to harness the three types of PCD for discovery of further novel drug targets, in the future cancer treatment.

TL;DR: Several small-molecule BET inhibitors and their relevant anti-tumor mechanisms are summarized to provide a clue for exploiting new targeted BET inhibitors in the future cancer therapy.

TL;DR: This review focuses on highlighting several representative plant natural compounds – curcumin, resveratrol, paclitaxel, oridonin, quercetin and plant lectin – that may lead to cancer cell death – for regulation of some core autophagic pathways involved in Ras‐Raf signalling, Beclin‐1 interactome, BCR‐ABL, PI3KCI/Akt/mTOR, FOXO1 signalling and p53.

TL;DR: The role of some autophagy-related kinase targets and kinase-mediated phosphorylation mechanisms in autophagic regulation is described and the small-molecule kinase inhibitors/activators of these targets are summarized, highlighting the opportunities of these new therapeutic agents.

TL;DR: A comprehensive review of the structure, function and modulators of Sirtuins is presented, which is expected to be beneficial to relevant studies.