다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Machine Learning is the study of methods for programming computers to learn. Computers are applied to a wide range of tasks, and for most of these it is relatively easy for programmers to design and implement the necessary software. However, there are many tasks for which this is difficult or impossible. These can be divided into four general categories. First, there are problems for which there exist no human experts. For example, in modern automated manufacturing facilities, there is a need to predict machine failures before they occur by analyzing sensor readings. Because the machines are new, there are no human experts who can be interviewed by a programmer to provide the knowledge necessary to build a computer system. A machine learning system can study recorded data and subsequent machine failures and learn prediction rules. Second, there are problems where human experts exist, but where they are unable to explain their expertise. This is the case in many perceptual tasks, such as speech recognition, hand-writing recognition, and natural language understanding. Virtually all humans exhibit expert-level abilities on these tasks, but none of them can describe the detailed steps that they follow as they perform them. Fortunately, humans can provide machines with examples of the inputs and correct outputs for these tasks, so machine learning algorithms can learn to map the inputs to the outputs. Third, there are problems where phenomena are changing rapidly. In finance, for example, people would like to predict the future behavior of the stock market, of consumer purchases, or of exchange rates. These behaviors change frequently, so that even if a programmer could construct a good predictive computer program, it would need to be rewritten frequently. A learning program can relieve the programmer of this burden by constantly modifying and tuning a set of learned prediction rules. Fourth, there are applications that need to be customized for each computer user separately. Consider, for example, a program to filter unwanted electronic mail messages. Different users will need different filters. It is unreasonable to expect each user to program his or her own rules, and it is infeasible to provide every user with a software engineer to keep the rules up-to-date. A machine learning system can learn which mail messages the user rejects and maintain the filtering rules automatically. Machine learning addresses many of the same research questions as the fields of statistics, data mining, and psychology, but with differences of emphasis. Statistics focuses on understanding the phenomena that have generated the data, often with the goal of testing different hypotheses about those phenomena. Data mining seeks to find patterns in the data that are understandable by people. Psychological studies of human learning aspire to understand the mechanisms underlying the various learning behaviors exhibited by people (concept learning, skill acquisition, strategy change, etc.).

Machine learning

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

Pattern Recognition and Machine Learning

Object detection is one of the most important and challenging branches of computer vision, which has been widely applied in people's life, such as monitoring security, autonomous driving and so on, with the purpose of locating instances of semantic objects of a certain class. With the rapid development of deep learning algorithms for detection tasks, the performance of object detectors has been greatly improved. In order to understand the main development status of object detection pipeline thoroughly and deeply, in this survey, we analyze the methods of existing typical detection models and describe the benchmark datasets at first. Afterwards and primarily, we provide a comprehensive overview of a variety of object detection methods in a systematic manner, covering the one-stage and two-stage detectors. Moreover, we list the traditional and new applications. Some representative branches of object detection are analyzed as well. Finally, we discuss the architecture of exploiting these object detection methods to build an effective and efficient system and point out a set of development trends to better follow the state-of-the-art algorithms and further research.

A Survey of Deep Learning-Based Object Detection

Recently, MOEA/D multi-objective evolutionary algorithm based on decomposition has achieved great success in the field of evolutionary multi-objective optimization and has attracted a lot of attention. It decomposes a multi-objective optimization problem MOP into a set of scalar subproblems using uniformly distributed aggregation weight vectors and provides an excellent general algorithmic framework of evolutionary multi-objective optimization. Generally, the uniformity of weight vectors in MOEA/D can ensure the diversity of the Pareto optimal solutions, however, it cannot work as well when the target MOP has a complex Pareto front PF; i.e., discontinuous PF or PF with sharp peak or low tail. To remedy this, we propose an improved MOEA/D with adaptive weight vector adjustment MOEA/D-AWA. According to the analysis of the geometric relationship between the weight vectors and the optimal solutions under the Chebyshev decomposition scheme, a new weight vector initialization method and an adaptive weight vector adjustment strategy are introduced in MOEA/D-AWA. The weights are adjusted periodically so that the weights of subproblems can be redistributed adaptively to obtain better uniformity of solutions. Meanwhile, computing efforts devoted to subproblems with duplicate optimal solution can be saved. Moreover, an external elite population is introduced to help adding new subproblems into real sparse regions rather than pseudo sparse regions of the complex PF, that is, discontinuous regions of the PF. MOEA/D-AWA has been compared with four state of the art MOEAs, namely the original MOEA/D, Adaptive-MOEA/D, -MOEA/D, and NSGA-II on 10 widely used test problems, two newly constructed complex problems, and two many-objective problems. Experimental results indicate that MOEA/D-AWA outperforms the benchmark algorithms in terms of the IGD metric, particularly when the PF of the MOP is complex.

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Moea/d with adaptive weight adjustment

This paper presents a novel change detection approach for synthetic aperture radar images based on deep learning. The approach accomplishes the detection of the changed and unchanged areas by designing a deep neural network. The main guideline is to produce a change detection map directly from two images with the trained deep neural network. The method can omit the process of generating a difference image (DI) that shows difference degrees between multitemporal synthetic aperture radar images. Thus, it can avoid the effect of the DI on the change detection results. The learning algorithm for deep architectures includes unsupervised feature learning and supervised fine-tuning to complete classification. The unsupervised feature learning aims at learning the representation of the relationships between the two images. In addition, the supervised fine-tuning aims at learning the concepts of the changed and unchanged pixels. Experiments on real data sets and theoretical analysis indicate the advantages, feasibility, and potential of the proposed method. Moreover, based on the results achieved by various traditional algorithms, respectively, deep learning can further improve the detection performance.

Change Detection in Synthetic Aperture Radar Images Based on Deep Neural Networks

An admissible support vector (SV) kernel (the wavelet kernel), by which we can construct a wavelet support vector machine (SVM), is presented. The wavelet kernel is a kind of multidimensional wavelet function that can approximate arbitrary nonlinear functions. The existence of wavelet kernels is proven by results of theoretic analysis. Computer simulations show the feasibility and validity of wavelet support vector machines (WSVMs) in regression and pattern recognition.

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Wavelet support vector machine

A novel algorithm, the immune genetic algorithm (IGA), is proposed based on the theory of immunity in biology which mainly constructs an immune operator accomplished by two steps: 1) a vaccination and 2) an immune selection. IGA proves theoretically convergent with probability 1. Strategies and methods of selecting vaccines and constructing an immune operator are also given. IGA is illustrated to be able to restrain the degenerate phenomenon effectively during the evolutionary process with examples of TSP, and can improve the searching ability and adaptability, greatly increase the convergence rate.

Licheng Jiao

Papers

A Survey of Deep Learning-Based Object Detection

Moea/d with adaptive weight adjustment

Change Detection in Synthetic Aperture Radar Images Based on Deep Neural Networks

Wavelet support vector machine

A novel genetic algorithm based on immunity