L
Lidenys Varela
Researcher at Johns Hopkins University
Publications - 6
Citations - 213
Lidenys Varela is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Macrophage migration inhibitory factor & Proto-oncogene tyrosine-protein kinase Src. The author has an hindex of 5, co-authored 6 publications receiving 179 citations. Previous affiliations of Lidenys Varela include University of Texas Medical Branch.
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Journal ArticleDOI
Organelle-Specific, Rapid Induction of Molecular Activities and Membrane Tethering
Toru Komatsu,Igor Kukelyansky,J. Michael McCaffery,Tasuku Ueno,Lidenys Varela,Takanari Inoue +5 more
TL;DR: This work activated Ras GTPase at distinct intracellular locations and induced tethering of membranes from two organelles, endoplasmic reticulum and mitochondria, using new chemically inducible dimerization probes.
Journal ArticleDOI
Macrophage Migration Inhibitory Factor Is a Novel Determinant of Cigarette Smoke–Induced Lung Damage
Jonathan Fallica,Laurent Boyer,Bo Kim,Leonid Serebreni,Lidenys Varela,Omar Hamdan,Lan Wang,Tiffany Simms,Mahendra Damarla,Todd M. Kolb,Richard Bucala,Wayne Mitzner,Paul M. Hassoun,Rachel L. Damico +13 more
TL;DR: Taken together, MIF appears to antagonize CS-induced toxicity in the lung and resultant emphysematous tissue remodeling by suppressing EC DNA damage and controlling p53-mediated apoptosis, highlighting a critical role of MIF in EC homeostasis within the lung.
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Macrophage Migration Inhibitory Factor: A Novel Inhibitor of Apoptosis Signal-Regulating Kinase 1-p38-Xanthine Oxidoreductase-Dependent Cigarette Smoke-Induced Apoptosis.
Jonathan Fallica,Lidenys Varela,Laura Johnston,Bo Kim,Leonid Serebreni,Lan Wang,Mahendra Damarla,Todd M. Kolb,Paul M. Hassoun,Rachel L. Damico +9 more
TL;DR: It is demonstrated that both the activity of xanthine oxidoreductase (XOR), a superoxide-generating enzyme obligatory for CS-induced DNA damage and EndoC apoptosis, and superoxide concentrations are increased after CS exposure in the absence of MIF.
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mTOR Signaling Feedback Modulates Mammary Epithelial Differentiation and Restrains Invasion Downstream of PTEN Loss
TL;DR: It is found that mTOR signaling promoted basal-like differentiation and repressed nuclear hormone receptor expression after short-term PTEN loss in murine cell cultures analyzed ex vivo, and that PTEN inactivation inhibited growth factor-induced epithelial invasion and that downstream mTOR-mediated signaling feedback was both necessary and sufficient for this effect.
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Functional Impact of Human Genetic Variants of COL18A1/Endostatin on Pulmonary Endothelium.
Alice M. Goyanes,Aigul Moldobaeva,Mery Marimoutou,Lidenys Varela,Lan Wang,Laura Johnston,Meena M. Aladdin,Grace Peloquin,Bo S. Kim,Mahendra Damarla,Karthik Suresh,Takahiro Sato,Todd M. Kolb,Paul M. Hassoun,Rachel L. Damico +14 more
TL;DR: It is demonstrated that ES inhibits PEC migration, proliferation and cell survival, with significant differences between human variants, indicating they are functional genetic variants.