L
Lieke E.J.M. Scheepers
Researcher at AstraZeneca
Publications - 15
Citations - 409
Lieke E.J.M. Scheepers is an academic researcher from AstraZeneca. The author has contributed to research in topics: Uric acid & Gout. The author has an hindex of 8, co-authored 15 publications receiving 286 citations. Previous affiliations of Lieke E.J.M. Scheepers include Utrecht University & University of Gothenburg.
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Journal ArticleDOI
The intestinal microbiota composition and weight development in children: the KOALA Birth Cohort Study
Lieke E.J.M. Scheepers,John Penders,Catherine A. Mbakwa,Carel Thijs,Monique Mommers,Ilja C. W. Arts +5 more
TL;DR: The KOALA Birth Cohort Study concludes that the intestinal microbiota, particularly the B. fragilis group, is associated with childhood weight development.
Journal ArticleDOI
Medication adherence among patients with gout: A systematic review and meta-analysis.
Lieke E.J.M. Scheepers,Marloes van Onna,Coen D.A. Stehouwer,Jasvinder A. Singh,Ilja C. W. Arts,Annelies Boonen +5 more
TL;DR: Medication adherence to ULT among gout patients was poor and strong evidence for a positive association with older age, more comorbidities, and the presence of diabetes or hypertension was found.
Journal ArticleDOI
Urate and risk of Alzheimer's disease and vascular dementia: A population-based study
Lieke E.J.M. Scheepers,Lennart T H Jacobsson,Silke Kern,Lena Johansson,Mats Dehlin,Ingmar Skoog +5 more
TL;DR: Low serum urate (sU) has been suggested to increase the risk of dementia since a reduction might impair antioxidant capacity, and high sU is associated with increased cardiovascular risk which might increase therisk of dementia, especially for vascular dementia.
Journal ArticleDOI
Medication adherence among gout patients initiated allopurinol: a retrospective cohort study in the Clinical Practice Research Datalink (CPRD)
Lieke E.J.M. Scheepers,Lieke E.J.M. Scheepers,Andrea M. Burden,Andrea M. Burden,Ilja C. W. Arts,Bart Spaetgens,Bart Spaetgens,Patrick C. Souverein,Frank de Vries,Frank de Vries,Annelies Boonen +10 more
TL;DR: Medication adherence among gout patients starting allopurinol is poor, particularly among females and younger patients and patients with fewer comorbidities, and in those reinitiating after a first gap.
Journal ArticleDOI
Xanthine oxidase gene variants and their association with blood pressure and incident hypertension : a population study
Lieke E.J.M. Scheepers,Fang Fei Wei,Katarzyna Stolarz-Skrzypek,Sofia Malyutina,Valérie Tikhonoff,Lutgarde Thijs,Erika Salvi,Cristina Barlassina,Jan Filipovský,Edoardo Casiglia,Yuri Nikitin,Kalina Kawecka-Jaszcz,Paolo Manunta,Daniele Cusi,Annelies Boonen,Jan A. Staessen,Ilja C. W. Arts +16 more
TL;DR: It is suggested that variation in uric acid production, as captured by genetic variation in XOR, might be a predictor of changes in BP and in the risk of hypertension.