S
Silke Kern
Researcher at University of Gothenburg
Publications - 110
Citations - 2963
Silke Kern is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Population & Dementia. The author has an hindex of 22, co-authored 73 publications receiving 1417 citations. Previous affiliations of Silke Kern include UCL Institute of Neurology & Mayo Clinic.
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Journal ArticleDOI
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.
Douglas P Wightman,Iris E. Jansen,Jeanne E. Savage,Alexey A. Shadrin,Shahram Bahrami,Shahram Bahrami,Dominic Holland,Arvid Rongve,Sigrid Børte,Sigrid Børte,Sigrid Børte,Bendik S. Winsvold,Bendik S. Winsvold,Ole Kristian Drange,Amy E Martinsen,Amy E Martinsen,Amy E Martinsen,Anne Heidi Skogholt,Cristen J. Willer,Geir Bråthen,Ingunn Bosnes,Ingunn Bosnes,Jonas B. Nielsen,Jonas B. Nielsen,Jonas B. Nielsen,Lars G. Fritsche,Laurent F. Thomas,Linda M. Pedersen,Maiken Elvestad Gabrielsen,Marianne Bakke Johnsen,Marianne Bakke Johnsen,Marianne Bakke Johnsen,Tore Wergeland Meisingset,Wei Zhou,Wei Zhou,Petroula Proitsi,Angela Hodges,Richard Dobson,Latha Velayudhan,Karl Heilbron,Adam Auton,Julia M. Sealock,Lea K. Davis,Nancy L. Pedersen,Chandra A. Reynolds,Ida K. Karlsson,Ida K. Karlsson,Sigurdur H. Magnusson,Hreinn Stefansson,Steinunn Thordardottir,Palmi V. Jonsson,Jon Snaedal,Anna Zettergren,Ingmar Skoog,Ingmar Skoog,Silke Kern,Silke Kern,Margda Waern,Margda Waern,Henrik Zetterberg,Kaj Blennow,Kaj Blennow,Eystein Stordal,Eystein Stordal,Kristian Hveem,John-Anker Zwart,John-Anker Zwart,John-Anker Zwart,Lavinia Athanasiu,Lavinia Athanasiu,Per Selnes,Ingvild Saltvedt,Sigrid Botne Sando,Ingun Ulstein,Srdjan Djurovic,Srdjan Djurovic,Tormod Fladby,Tormod Fladby,Dag Aarsland,Dag Aarsland,Geir Selbæk,Geir Selbæk,Stephan Ripke,Stephan Ripke,Stephan Ripke,Kari Stefansson,Ole A. Andreassen,Ole A. Andreassen,Danielle Posthuma,Danielle Posthuma +89 more
TL;DR: This paper identified microglia, immune cells and protein catabolism as relevant genes for late-onset Alzheimer's disease, while identifying and prioritizing previously unidentified genes of potential interest.
Journal ArticleDOI
Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype
Lisa Vermunt,Sietske A.M. Sikkes,Ardo van den Hout,Ron Handels,Isabelle Bos,Wiesje M. van der Flier,Silke Kern,P.J. Ousset,Paul Maruff,Ingmar Skoog,Frans R.J. Verhey,Yvonne Freund-Levi,Magda Tsolaki,Åsa K. Wallin,Marcel G. M. Olde Rikkert,Hilkka Soininen,Luisa Spiru,Henrik Zetterberg,Kaj Blennow,Philip Scheltens,Graciela Muniz-Terrera,Pieter Jelle Visser +21 more
TL;DR: The age‐specific duration of the preclinical, prodromal, and dementia stages of Alzheimer's disease and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration are estimated.
Journal ArticleDOI
White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities
Jessica Alber,Suvarna Alladi,Hee-Joon Bae,David Barton,Laurel A. Beckett,Joanne Bell,Sara E. Berman,Geert Jan Biessels,Sandra E. Black,Isabelle Bos,Gene L. Bowman,Gene L. Bowman,Emanuele Brai,Adam M. Brickman,Brandy L. Callahan,Roderick A. Corriveau,Silvia Fossati,Rebecca F. Gottesman,Deborah Gustafson,Vladimir Hachinski,Kathleen M. Hayden,Alex M. Helman,Timothy M. Hughes,Jeremy D. Isaacs,Angela L. Jefferson,Sterling C. Johnson,Alifiya Kapasi,Silke Kern,Jay C. Kwon,Juraj Kukolja,Athene Lee,Samuel N. Lockhart,Anne M. Murray,Katie E. Osborn,Melinda C. Power,Brittani R. Price,Hanneke F.M. Rhodius-Meester,Jacqueline A. Rondeau,Allyson C. Rosen,Douglas L. Rosene,Julie A. Schneider,Henrieta Scholtzova,C Elizabeth Shaaban,Narlon C. Boa Sorte Silva,Heather M. Snyder,Walter Swardfager,Aron M. Troen,Susanne J. van Veluw,Prashanthi Vemuri,Anders Wallin,Cheryl L. Wellington,Donna M. Wilcock,Sharon X. Xie,Atticus H. Hainsworth +53 more
TL;DR: Outstanding questions about white matter hyperintensities and their relation to cognition, dementia, and AD are identified and answered to improve prevention and treatment of WMHs and dementia.
Journal ArticleDOI
Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium.
Frank J. Wolters,Frank J. Wolters,Lori B. Chibnik,Reem Waziry,Roy M. Anderson,Claudine Berr,Alexa S. Beiser,Joshua C. Bis,Deborah Blacker,Daniel Bos,Daniel Bos,Carol Brayne,Jean-François Dartigues,Sirwan K.L. Darweesh,Kendra Davis-Plourde,Frank de Wolf,Stéphanie Debette,Carole Dufouil,Myriam Fornage,Jaap Goudsmit,Leslie Grasset,Vilmundur Gudnason,Christoforos Hadjichrysanthou,Catherine Helmer,M. Arfan Ikram,M. Kamran Ikram,Erik Joas,Silke Kern,Lewis H. Kuller,Lenore J. Launer,Oscar L. Lopez,Fiona E. Matthews,Kevin McRae-McKee,Osorio Meirelles,Thomas H. Mosley,Matthew P. Pase,Bruce M. Psaty,Bruce M. Psaty,Claudia L. Satizabal,Claudia L. Satizabal,Sudha Seshadri,Sudha Seshadri,Ingmar Skoog,Blossom C. M. Stephan,Hanna Wetterberg,Mei Mei Wong,Anna Zettergren,Albert Hofman,Albert Hofman +48 more
TL;DR: The incidence rate of dementia in Europe and North America has declined by 13% per decade over the past 25 years, consistently across studies, and somewhat more pronouncedly in men than in women.
Journal ArticleDOI
Plasma and CSF neurofilament light: Relation to longitudinal neuroimaging and cognitive measures.
Michelle M. Mielke,Jeremy A. Syrjanen,Kaj Blennow,Henrik Zetterberg,Prashanthi Vemuri,Ingmar Skoog,Mary M. Machulda,Walter K. Kremers,David S. Knopman,Clifford R. Jack,Ronald C. Petersen,Silke Kern +11 more
TL;DR: Elevated baseline plasma NfL is a prognostic marker of cognitive decline and neuroimaging measures of neurodegeneration, and has similar effect sizes to baseline CSF N fL.