J
John Penders
Researcher at Maastricht University
Publications - 170
Citations - 12463
John Penders is an academic researcher from Maastricht University. The author has contributed to research in topics: Gut flora & Microbiome. The author has an hindex of 46, co-authored 142 publications receiving 9833 citations. Previous affiliations of John Penders include Ghent University Hospital & Maastricht University Medical Centre.
Papers
More filters
Journal ArticleDOI
Factors influencing the composition of the intestinal microbiota in early infancy
John Penders,Carel Thijs,Carel Thijs,Cornelis Vink,Foekje Stelma,Bianca E. P. Snijders,Ischa Kummeling,Piet A. van den Brandt,Ellen E. Stobberingh +8 more
TL;DR: The most important determinants of the gut microbiotic composition in infants were the mode of delivery, type of infant feeding, gestational age, infant hospitalization, and antibiotic use by the infant.
Journal ArticleDOI
Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer.
Christian J. H. von Wintersdorff,John Penders,Julius M. van Niekerk,Nathan D. Mills,Snehali Majumder,Lieke B. van Alphen,Paul H. M. Savelkoul,Paul H. M. Savelkoul,Petra F. G. Wolffs +8 more
TL;DR: The concept of the resistome is discussed, examples of HGT of clinically relevant ARGs are provided and an overview of the current knowledge of the contributions the various HGT mechanisms make to the spread of antibiotic resistance is presented.
Journal ArticleDOI
Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study
John Penders,Carel Thijs,Piet A. van den Brandt,Ischa Kummeling,Bianca E. P. Snijders,Foekje Stelma,Hanne Adams,Ronald van Ree,Ellen E. Stobberingh +8 more
TL;DR: In this article, Gut microbiota composition in early infancy and the subsequent development of atopic manifestations and sensitisation was examined, and the presence of Escherichia coli was associated with a higher risk of developing eczema (OR adj ǫ= 1.87; 95% CI 1.15 to 3.04).
Journal ArticleDOI
Towards standards for human fecal sample processing in metagenomic studies
Paul I. Costea,Georg Zeller,Shinichi Sunagawa,Eric Pelletier,Eric Pelletier,Adriana Alberti,Florence Levenez,Melanie Tramontano,Marja Driessen,Rajna Hercog,Ferris Elias Jung,Jens Roat Kultima,Matthew R. Hayward,Luis Pedro Coelho,Emma Allen-Vercoe,Laurie Bertrand,Michael Blaut,Jillian R.M. Brown,Thomas Carton,Stéphanie Cools-Portier,Michelle C. Daigneault,Muriel Derrien,Anne Druesne,Willem M. de Vos,Willem M. de Vos,B. Brett Finlay,Harry J. Flint,Francisco Guarner,Masahira Hattori,Masahira Hattori,Hans G.H.J. Heilig,Ruth Ann Luna,Johan E. T. van Hylckama Vlieg,Jana Junick,Ingeborg Klymiuk,Philippe Langella,Volker Mai,Chaysavanh Manichanh,Jennifer C. Martin,Clémentine Mery,Hidetoshi Morita,Paul W. O'Toole,Céline Orvain,Kiran Raosaheb Patil,John Penders,Søren Persson,Nicolas Pons,Milena Popova,Anne Salonen,Delphine M. Saulnier,Karen P. Scott,Bhagirath Singh,Kathleen Slezak,Patrick Veiga,James Versalovic,Liping Zhao,Erwin G. Zoetendal,S. Dusko Ehrlich,S. Dusko Ehrlich,Joël Doré,Peer Bork +60 more
TL;DR: A standardized DNA extraction method for human fecal samples is recommended, for which transferability across labs was established and which was further benchmarked using a mock community of known composition to improve comparability of human gut microbiome studies and facilitate meta-analyses.
Journal ArticleDOI
Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy
Frederika A. van Nimwegen,John Penders,Ellen E. Stobberingh,Dirkje S. Postma,Gerard H. Koppelman,Marjan Kerkhof,Naomi E. Reijmerink,Edward Dompeling,Piet A. van den Brandt,Isabel Ferreira,Monique Mommers,Carel Thijs +11 more
TL;DR: Mediation analysis showed that the effects of mode and place of delivery on atopic outcomes were mediated by C difficile colonization, and Vaginal home delivery compared with vaginal hospital delivery was associated with a decreased risk of eczema, sensitization to food allergens, and asthma.