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Lígia M. Saraiva

Researcher at Universidade Nova de Lisboa

Publications -  133
Citations -  4731

Lígia M. Saraiva is an academic researcher from Universidade Nova de Lisboa. The author has contributed to research in topics: Cytochrome & Heme. The author has an hindex of 35, co-authored 127 publications receiving 4293 citations. Previous affiliations of Lígia M. Saraiva include University of Kent & Technical University of Lisbon.

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NADH oxidase activity of mitochondrial apoptosis-inducing factor.

TL;DR: Biochemical characterization of AIF's redox activity indicates that AIF has a marked oxidoreductase activity which can be dissociated from its apoptosis-inducing function.
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New Genes Implicated in the Protection of Anaerobically Grown Escherichia coli against Nitric Oxide

TL;DR: A new set of Escherichia coli K-12 genes conferring anaerobic resistance to nitric oxide is presented, namely the gene product of YtfE and a potential transcriptional regulator of the helix-turn-helix LysR-type (YidZ).
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A Novel Type of Nitric-oxide Reductase ESCHERICHIA COLI FLAVORUBREDOXIN

TL;DR: A novel family of prokaryotic NO reductases, with a non-heme di-iron site as the catalytic center, was established, and was shown that the activity was due to the A-type flavoprotein core, as the rubredoxin domain alone exhibited no activity.
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[NiFe] hydrogenase from Desulfovibrio desulfuricans ATCC 27774: gene sequencing, three-dimensional structure determination and refinement at 1.8 A and modelling studies of its interaction with the tetrahaem cytochrome c3.

TL;DR: The lowest energy docking solutions were found to correspond to an interaction between the haem IV region in tetrahaem cytochrome c3 with the distal [4Fe-4S] cluster in [NiFe] hydrogenase, which should correspond to efficient electron transfer and be physiologically relevant.
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Antimicrobial Action of Carbon Monoxide-Releasing Compounds

TL;DR: The results constitute the first evidence that CO can be utilized as an antimicrobial agent and are expected to be the starting point for the development of novel types of therapeutic drugs designed to combat antibiotic-resistant pathogens, which are widespread and presently a major public health concern.