L
Luigi Ravagnan
Researcher at Centre national de la recherche scientifique
Publications - 20
Citations - 8302
Luigi Ravagnan is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Mitochondrion & Apoptosis. The author has an hindex of 17, co-authored 20 publications receiving 8070 citations. Previous affiliations of Luigi Ravagnan include Institut Gustave Roussy.
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Journal ArticleDOI
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death
Nicholas Joza,Nicholas Joza,Santos A. Susin,Eric Daugas,William L. Stanford,Sarah K. Cho,Carol Y. J. Li,Takehiko Sasaki,Takehiko Sasaki,Andrew J. Elia,H.-Y. Mary Cheng,H.-Y. Mary Cheng,Luigi Ravagnan,Karine F. Ferri,Naoufal Zamzami,Andrew Wakeham,Razqallah Hakem,Hiroki Yoshida,Young-Yun Kong,Tak W. Mak,Juan Carlos Zúñiga-Pflücker,Guido Kroemer,Josef M. Penninger,Josef M. Penninger +23 more
TL;DR: It is shown that genetic inactivation of AIF renders embryonic stem cells resistant to cell death after serum deprivation, providing genetic evidence for a caspase-independent pathway of programmed cell death that controls early morphogenesis.
Journal ArticleDOI
Hsp27 negatively regulates cell death by interacting with cytochrome c
Jean-Marie Bruey,Cécile Ducasse,Philippe Bonniaud,Luigi Ravagnan,Santos A. Susin,Chantal Diaz-Latoud,Sandeep Gurbuxani,André-Patrick Arrigo,Guido Kroemer,Eric Solary,Carmen Garrido +10 more
TL;DR: Hsp27 binds to cytochrome c released from the mitochondria to the cytosol and prevents cy tochrome-c-mediated interaction of Apaf-1 with procaspase-9, which interferes specifically with the mitochondrial pathway of caspases-dependent cell death.
Journal ArticleDOI
Heat-shock protein 70 antagonizes apoptosis-inducing factor.
Luigi Ravagnan,Sandeep Gurbuxani,Santos A. Susin,Carine Maisse,Eric Daugas,Naoufal Zamzami,Tak W. Mak,Marja Jäättelä,Josef M. Penninger,Carmen Garrido,Guido Kroemer +10 more
TL;DR: The data indicate that Hsp70 can inhibit apoptosis by interfering with target proteins other than Apaf-1, one of which is AIF, which is a mitochondrial intermembrane flavoprotein.
Journal ArticleDOI
Heat shock proteins: endogenous modulators of apoptotic cell death.
TL;DR: A review of apoptosis-regulatory function of HSPs concludes that HSP27 and HSP70 may participate in carcinogenesis and should be considered as suspects in the development of cancer.
Journal ArticleDOI
Two distinct pathways leading to nuclear apoptosis.
Santos A. Susin,Eric Daugas,Luigi Ravagnan,Kumiko Samejima,Naoufal Zamzami,Markus Loeffler,Paola Costantini,Karine F. Ferri,Theano Irinopoulou,Marie-Christine Prévost,Tak W. Mak,Josef M. Penninger,William C. Earnshaw,Guido Kroemer +13 more
TL;DR: Two redundant parallel pathways may lead to chromatin processing during apoptosis, including one which involves Apaf-1 and caspases, as well as CAD, and leads to oligonucleosomal DNA fragmentation and advanced chromatin condensation and the other which is caspase-independent.